9-顺式视黄醛
9-顺式视黄醛结构式
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常用名 | 9-顺式视黄醛 | 英文名 | 9-cis-Retinal |
|---|---|---|---|---|
| CAS号 | 514-85-2 | 分子量 | 284.436 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 421.4±14.0 °C at 760 mmHg | |
| 分子式 | C20H28O | 熔点 | 56-58ºC(lit.) | |
| MSDS | 美版 | 闪点 | 205.4±12.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.
Invest. Ophthalmol. Vis. Sci. 56 , 2553-67, (2015) Inherent instability of the P23H mutant opsin accounts for approximately 10% of autosomal dominant retinitis pigmentosa cases. Our purpose was to develop an overall set of reliable screening strategies to assess if either stabilization or enhanced degradation... |
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Cubozoan genome illuminates functional diversification of opsins and photoreceptor evolution.
Sci. Rep. 5 , 11885, (2015) Animals sense light primarily by an opsin-based photopigment present in a photoreceptor cell. Cnidaria are arguably the most basal phylum containing a well-developed visual system. The evolutionary history of opsins in the animal kingdom has not yet been reso... |
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Constitutive phospholipid scramblase activity of a G protein-coupled receptor.
Nat. Commun. 5 , 5115, (2014) Opsin, the rhodopsin apoprotein, was recently shown to be an ATP-independent flippase (or scramblase) that equilibrates phospholipids across photoreceptor disc membranes in mammalian retina, a process required for disc homoeostasis. Here we show that scrambli... |
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QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles.
Invest. Ophthalmol. Vis. Sci. 54(1) , 455-66, (2013) Investigate whether retinas of mice with impaired retinal cycles exposed to light or kept in the dark tolerate prolonged high-dose administration of QLT091001, which contains as an active ingredient, the 9-cis-retinal precursor, 9-cis-retinyl acetate.Four- to... |
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A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids.
Invest. Ophthalmol. Vis. Sci. 53(10) , 6314-23, (2012) To design and develop a drug-delivery system containing a combination of poly(D,L-lactide-co-glycolide) (PLGA) microparticles and alginate hydrogel for sustained release of retinoids to treat retinal blinding diseases that result from an inadequate supply of ... |
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Asymmetry of the rhodopsin dimer in complex with transducin.
FASEB J. 27(4) , 1572-84, (2013) A large body of evidence for G-protein-coupled receptor (GPCR) oligomerization has accumulated over the past 2 decades. The smallest of these oligomers in vivo most likely is a dimer that buries 1000-Å(2) intramolecular surfaces and on stimulation forms a com... |
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Opsin activation of transduction in the rods of dark-reared Rpe65 knockout mice.
J. Physiol. 568(Pt 1) , 83-95, (2005) Rpe65 knockout mice (Rpe65-/-) are unable to synthesize the visual pigment chromophore 11-cis retinal; however, if these animals are reared in complete darkness, the rod photoreceptors accumulate a small amount of 9-cis retinal and its corresponding visual pi... |
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Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.
J. Steroid Biochem. Mol. Biol. 69(1-6) , 3-12, (1999) Nuclear receptors are ligand-inducible transcription factors which mediate the physiological effects of steroid, thyroid and retinoid hormones. By regulating the assembly of a transcriptional preinitiation complex at the promoter of target genes, they enhance... |
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The efficacy of 9-cis retinoic acid in experimental models of cancer.
Breast Cancer Res. Treat. 38(1) , 85-96, (1996) 9-cis retinoic acid (9-cis RA) is a retinoid receptor pan-agonist that binds with high affinity to both retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Using a variety of in vivo and in vitro cancer models, we present experimental data that 9-... |
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Melanopsin is highly resistant to light and chemical bleaching in vivo.
J. Biol. Chem. 287(25) , 20888-97, (2012) Melanopsin is the photopigment of mammalian intrinsically photosensitive retinal ganglion cells, where it contributes to light entrainment of circadian rhythms, and to the pupillary light response. Previous work has shown that the melanopsin photocycle is ind... |