阿尔吡登

Pharmacopsychiatry 23 Suppl 3 , 129-34, (1990)

This review analyzes the available data on the therapeutic activity of alpidem in various anxiety syndromes. Up to now, 17 studies have been completed in Europe, dealing with a total population of more than 1500 patients suffering from either chronic (n = 987...

J. Submicrosc. Cytol. Pathol. 28(1) , 5-12, (1996)

Hepatic stellate cells were studied by immuno-cytochemistry with anti smooth muscle alpha-actin antibody (an activation marker for these cells) and electron microscopy, in eleven patients transplanted for fulminant or subfulminant hepatitis. Numerous smooth m...

Pharmacopsychiatry 23 Suppl 3 , 120-3, (1990)

Alpidem, an imidazo-pyridine compound, has been evaluated as an anxiolytic in comparison with placebo and lorazepam. In the first of our normal volunteer studies, we compared single doses of alpidem, 25, 50 and 100 mg with lorazepam 2 mg and placebo on a rang...

J. Chromatogr. A. 668(2) , 403-11, (1994)

Alpidem, 6-chloro-2-(4-chlorophenyl)-N,N-dipropylimidazo[1,2-a]pyridine- 3-acetamide, is an anxiolytic imidazopyridine that undergoes a first-pass elimination after oral administration to humans; it is actively metabolized and three circulating metabolites ha...

Eur. J. Pharm. Sci. 18(3-4) , 231-40, (2003)

Alpidem analogues containing a GABA (1-3) or glycine (4-6) moiety were synthesized and their interaction with the GABA/benzodiazepine receptor complex at central (CBR) and peripheral (PBR) level was evaluated. In particular, their ability to modulate the spec...

J. Pharmacol. Exp. Ther. 273(2) , 842-9, (1995)

In the present study, we combined a powerful and novel receptor binding data analysis technique. Fourier-derived affinity spectrum analysis (FASA), with the nonlinear regression analysis program LIGAND to resolve benzodiazepine receptor heterogeneity in rat s...

Brain Res. 704(2) , 289-97, (1995)

The binding of [3H]Ro 15-4513, [3H]flunitrazepam and [3H]flumazenil to rat CNS membranes was studied at 2 degrees C, 22 degrees C and 37 degrees C using ligand concentrations ranging from approximately 0.06 nM to 10 microM. Analysis of the binding saturation ...

Pharmacopsychiatry 23 Suppl 3 , 124-8, (1990)

With increasing age there is a concurrent increase in the side effects following psychotropic medication. The necessity of measuring the magnitude of the extent of the side effects using a properly constructed psychometric test battery is illustrated with ref...

Eur. J. Pharmacol. 280(2) , 167-73, (1995)

An alpidem-insensitive benzodiazepine binding site in the rat spinal cord has recently been identified in our laboratory. We report here the binding of 23 1,4-benzodiazepines to this site using [3H]Ro15-4513 (ethyl-8-azido-6-dihydro-5-methyl-4H-imidazo[1,2- a...

Adv. Biochem. Psychopharmacol. 46 , 61-72, (1990)