MDL 11,939
MDL 11,939结构式
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常用名 | MDL 11,939 | 英文名 | MDL 11,939 |
|---|---|---|---|---|
| CAS号 | 107703-78-6 | 分子量 | 295.41900 | |
| 密度 | 1.084g/cm3 | 沸点 | 434.2ºC at 760mmHg | |
| 分子式 | C20H25NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 205.6ºC | |
| 符号 |
GHS09 |
信号词 | Warning |
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Selective remodeling of rabbit frontal cortex: relationship between 5-HT2A receptor density and associative learning.
Psychopharmacology 172(4) , 435-42, (2004) Associative learning during classical trace eyeblink conditioning has been shown to be regulated by serotonin 5-HT(2A )receptors and to be critically dependent on the integrity of frontal cortex. Chronic administration of 5-HT(2A) ligands has been shown to pr... |
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Effect of 5-HT2 receptor antagonists on a cranial nerve reflex in the rabbit: evidence for inverse agonism.
Psychopharmacology 141 , 162, (1999) This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying... |
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Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors.
Psychopharmacology 201(1) , 55-66, (2008) The hallucinogenic tea known as ayahuasca is made from a combination of psychoactive plants that contribute the active components N,N-dimethyltryptamine (DMT) and 5-methoxy-DMT (5-MeO-DMT), as well as the monoamine oxidase (MAO) inhibitors (MAOIs) harmine and... |
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A double dissociation in the effects of 5-HT2A and 5-HT2C receptors on the acquisition and expression of conditioned defeat in Syrian hamsters.
Behav. Neurosci. 126(4) , 530-7, (2012) Previous research indicates that serotonin enhances the development of stress-induced changes in behavior, although it is unclear which serotonin receptors mediate this effect. 5-HT2 receptors are potential candidates because activation at these receptors is ... |
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The time-course for up- and down-regulation of the cortical 5-hydroxytryptamine (5-HT)2A receptor density predicts 5-HT2A receptor-mediated behavior in the rabbit.
J. Pharmacol. Exp. Ther. 323(1) , 327-35, (2007) 5-Hydroxytryptamine (serotonin; 5-HT)2 receptor agonists such as (+/-)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) injected systemically or directly into frontal cortex, elicit stereotyped head movements that are mediated by 5-HT2A receptors. Chronic ad... |
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Efficacy trial of the 5-HT2 antagonist MDL 11,939 in patients with generalized anxiety disorder.
J. Clin. Psychopharmacol. 15(1) , 20-2, (1995) The purpose of this study was to assess the anxiolytic effect of MDL 11,939, a selective 5-HT2 receptor antagonist, in patients with generalized anxiety disorder. After a 1-week placebo lead-in period, 72 healthy male outpatients meeting DSM-III-R criteria fo... |
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Serotonin 5-HT2A receptors in the CA1 field of the hippocampus mediate head movements in the rabbit.
Psychopharmacology 176(3-4) , 287-95, (2004) Motor movements (head bobs) in the rabbit have been shown to be elicited by LSD-like hallucinogenic drugs through actions at central serotonin 5-HT(2A) receptors, though their central locus remains unknown. Serotonergic innervation of the hippocampus has been... |
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alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.
Eur. J. Pharmacol. 517(1-2) , 51-8, (2005) The aim of the present study was to investigate the modulation of locus coeruleus neurons by the selective serotonin (5-HT) reuptake inhibitor citalopram using single-unit extracellular recordings in rat brain slices. Citalopram inhibited the activity of a su... |
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Action of serotonin in the medial prefrontal cortex: mediation by serotonin3-like receptors.
Synapse 10(1) , 7-15, (1992) In the present study, we investigated the effects of various serotonin (5-HT) antagonists on 5-HT's action on medial prefrontal cortical cells (mPFc) using the techniques of single cell recording and microiontophoresis. The microiontophoretic application of 5... |
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Attenuating the persistence of fear memory storage using a single dose of antidepressant.
Mol. Psychiatry 18(1) , 7-8, (2013)
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