萘普生杂质A

Int. J. Clin. Pharmacol. Ther. Toxicol. 26(4) , 190-3, (1988)

After a rectal dose of 500 mg in a suppository, naproxen is 6-O-demethylated (20%) and glucuronidated (40%), the metabolites are subsequently excreted renally. The elimination half-life is 15.2 +/- 2.6 h. Ten out of 22 subjects show biphasic elimination kinet...

Br. J. Clin. Pharmacol. 60(6) , 632-40, (2005)

Naproxen is a nonsteroidal anti-inflammatory drug widely used as an analgesic and anti-inflammatory agent. The conjugated forms of naproxen and O-DMN, its demethylated metabolite, account for 66-92% of naproxen found in human urine. In this study, O-DMN and s...

J. Chromatogr. A. 383(2) , 449-55, (1986)

Ann. Clin. Biochem. 24 ( Pt 2) , 177-81, (1987)

Interference by naproxen in the spectrophotometric assay for urinary 5-hydroxyindoleacetic acid has been investigated. Gas chromatography-mass spectrometry demonstrated that ingestion of naproxen was associated with the production of four urinary components, ...

Am. J. Clin. Pathol. 133(6) , 878-83, (2010)

A recent report indicated significant interference of naproxen with total bilirubin measurement when using the Jendrassik and Grof method. We explored the possibility of avoiding this interference by using a different method. We observed that naproxen has no ...

Hum. Exp. Toxicol. 13(12) , 831-8, (1994)

1. Rat liver microsomal suspension containing NADPH and MgCl2 was incubated at 37 degrees C with naproxen, a non-steroidal anti-inflammatory drug. Thiobarbituric acid reactive substances (TBA-RS), high molecular weight protein aggregates and fluorescent subst...

J. Chromatogr. A. 578(2) , 239-49, (1992)

Naproxen is metabolized in humans by O-demethylation, and by acyl glucuronidation to the 1-O-glucuronide. Naproxen, its metabolite and the conjugates can be measured directly by gradient high-performance liquid chromatographic analysis without enzymic deglucu...

Pharm. Res. 8(10) , 1223-30, (1991)

Low molecular weight proteins (LMWPs), such as lysozyme, may be suitable carriers to target drugs to the kidney. In this study the antiinflammatory drug naproxen was covalently bound to lysozyme (1:1). Pharmacokinetics of the conjugate, naproxen-lysozyme (nap...

Br. J. Clin. Pharmacol. 35(5) , 467-72, (1993)

1. The pharmacokinetics of 500 mg naproxen given orally were described in 10 subjects using a direct h.p.l.c. analysis of the acyl glucuronide conjugates of naproxen and its metabolite O-desmethylnaproxen. 2. The mean elimination half-life of naproxen was 24....

Clin. Pharmacokinet. 11(6) , 511-5, (1986)