盐酸氯丙嗪
盐酸氯丙嗪结构式
|
常用名 | 盐酸氯丙嗪 | 英文名 | Chlorpromazine hydrochloride |
|---|---|---|---|---|
| CAS号 | 69-09-0 | 分子量 | 355.325 | |
| 密度 | 1.077 g/cm3 (15 C) | 沸点 | 450.1ºC at 760 mmHg | |
| 分子式 | C17H20Cl2N2S | 熔点 | 192-196°C | |
| MSDS | 中文版 美版 | 闪点 | 9 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
|
Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells.
Nat. Commun. 6 , 6240, (2015) Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein f... |
|
|
Direct cellular delivery of human proteasomes to delay tau aggregation.
Nat. Commun. 5 , 5633, (2014) The 26S proteasome is the primary machinery that degrades ubiquitin (Ub)-conjugated proteins, including many proteotoxic proteins implicated in neurodegeneraton. It has been suggested that the elevation of proteasomal activity is tolerable to cells and may be... |
|
|
Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin.
Int. J. Pharm. 478(2) , 745-52, (2015) Inhibitors against multidrug resistance (MDR) efflux transporters have failed in most clinical settings due to unfavorable pharmacokinetic interactions with co-administered anti-cancer drug and their inherent toxicities. Nanoparticles (NPs) have shown potenti... |
|
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
Uptake of different crystal structures of TiO₂ nanoparticles by Caco-2 intestinal cells.
Toxicol. Lett. 226(3) , 264-76, (2014) The gastrointestinal uptake of different crystal structures of TiO2 was investigated using Caco-2 intestinal cells. Caco-2 monolayers exhibited time-dependent, saturable uptake of Ti from TiO2 exposures of 1 mgl(-1) over 24h, which was influenced by crystal t... |
|
|
Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.
Virology 458-459 , 190-208, (2014) Recently, cell culture systems producing hepatitis C virus particles (HCVcc) were developed. Establishment of serum-free culture conditions is expected to facilitate development of a whole-virus inactivated HCV vaccine. We describe generation of genotype 1-6 ... |
|
|
Liposomal drug deposits in poly(dopamine) coatings: effect of their composition, cell type, uptake pathway considerations, and shear stress.
Macromol. Biosci. 14(12) , 1677-87, (2014) Implantable devices equipped with coatings which have the ability to carry and deliver active compounds are of great interest. We report the assembly of liposome-containing poly(dopamine) films, and their interaction with adhering cells. The liposome composit... |
|
|
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
|
|
Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.
J. Appl. Toxicol. 35(2) , 152-64, (2014) Drug-induced liver injury (DILI) is a major safety concern during drug development and remains one of the main reasons for withdrawal of drugs from the market. Although it is crucial to develop methods that will detect potential hepatotoxicity of drug candida... |
|
|
Interaction of solutions containing phenothiazines exposed to laser radiation with materials surfaces, in view of biomedical applications.
Int. J. Pharm. 475(1-2) , 270-81, (2014) Phenothiazine drugs - chlorpromazine (CPZ), promazine (PZ) and promethazine (PMZ) - were exposed to 266 nm (fourth harmonic of the Nd:YAG pulsed laser radiation) in order to be modified at molecular level and to produce an enhancement of their antibacterial a... |