多拉菌素
多拉菌素结构式
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常用名 | 多拉菌素 | 英文名 | Doramectin |
|---|---|---|---|---|
| CAS号 | 117704-25-3 | 分子量 | 899.114 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 967.4±65.0 °C at 760 mmHg | |
| 分子式 | C50H74O14 | 熔点 | 116 - 119ºC | |
| MSDS | 中文版 美版 | 闪点 | 274.4±27.8 °C | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Anthelmintic resistance in a herd of alpacas (Vicugna pacos).
Can. Vet. J. 53(12) , 1310-3, (2012) A herd of alpacas was examined because of a history of severe endoparasitism, anemia, hypoproteinemia, and weight loss. Resistance of gastrointestinal nematodes to albendazole, fenbendazole, and doramectin was documented. This report suggests that anthelminti... |
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Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin.
J. Pharm. Pharmacol. 62(3) , 393-9, (2010) Multidrug resistance (MDR) is a serious obstacle encountered in cancer treatment. This study was performed to explore the reversal of MDR by doramectin from the avermectin family and nemadectin belonging to the milbemycin family.The MTT assay was used to eval... |
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The influence of gastrointestinal parasitism on fecal elimination of doramectin, in lambs.
Ecotoxicol. Environ. Saf. 73(8) , 2017-21, (2010) A study was done to investigate the effect of parasitism on patterns of doramectin (DRM) fecal elimination in lambs. Fourteen Suffolk Down parasitized lambs (26.9 ± 1.5 kg body weight: bw) were purposely selected for the study. Seven pairs of lambs were alloc... |
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Influence of P-glycoprotein inhibition on secretion of ivermectin and doramectin by milk in lactating sheep.
Vet. Parasitol. 179(1-3) , 159-66, (2011) The aim of to the present study was to evaluate the effects of verapamil (VER) on plasma pharmacokinetics of ivermectin (IVM) and doramectin (DOR) in lactating Istrian Pramenka dairy sheep and to investigate the role of P-glycoprotein (P-gp) in transport of a... |
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Production of doramectin by rational engineering of the avermectin biosynthetic pathway
Bioorg. Med. Chem. Lett. 21(11) , 3320-3, (2011) In an attempt to construct a strain that produces doramectin, the loading module of Ave polyketide synthase (PKS) from Streptomyces avermitilis M1 was replaced with a cyclohexanecarboxylic (CHC) unique loading module from phoslactomycin PKS. Additionally, the... |
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Analysis of doramectin in the serum of repeatedly treated pastured cattle used to predict the probability of cattle fever ticks (Acari: Ixodidae) feeding to repletion.
Exp. Appl. Acarol. 56(4) , 365-74, (2012) Analysis of doramectin concentration in blood serum of pastured cattle injected repeatedly (12 treatments) at two different dosage rates and 28-day intervals throughout the year was used to predict the probability that cattle fever ticks could successfully fe... |
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An alternative derivatization reaction to the determination of doramectin in bovine milk using spectrofluorimetry.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 100 , 127-30, (2013) The doramectin (DOR), which belongs to the avermectins group (AVM), has a high antiparasitic activity and so it has been widely used in food-producing animals. The DOR shows low fluorescence quantum efficiency and as a consequence, chemical derivatization rea... |
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Four new doramectin congeners with acaricidal and insecticidal activity from Streptomyces avermitilis NEAU1069.
Chem. Biodivers. 8(11) , 2117-25, (2011) Four new doramectin congeners, 1-4, were isolated from Streptomyces avermitilis NEAU1069. The structures of 1-4 were elucidated on the basis of spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS, ESI-MS, UV, and IR, and comparison with lite... |
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Two new doramectin analogs from Streptomyces avermitilis NEAU1069: fermentation, isolation and structure elucidation.
J. Antibiot. 64(8) , 591-4, (2011)
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Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits.
Lab. Anim. 44(2) , 138-42, (2010) This study evaluated the comparative plasma dispositions of ivermectin (IVM), doramectin (DRM) and moxidectin (MXD) following subcutaneous administration in rabbits. Fifteen New Zealand white rabbits were allocated into three groups of five animals each. The ... |