维生素 K1
维生素 K1结构式
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常用名 | 维生素 K1 | 英文名 | Vitamin K1 |
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| CAS号 | 84-80-0 | 分子量 | 450.696 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 546.4±50.0 °C at 760 mmHg | |
| 分子式 | C31H46O2 | 熔点 | −20 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 200.4±27.1 °C |
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Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos.
J. Chromatogr. A. 1412 , 59-66, (2015) The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Recently, the zebrafish has been adopted as a valuable animal model system to perform in vivo metabolomics studies, however limited methodologies and pr... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.
Eur. J. Med. Chem. 43 , 714-40, (2008) Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and organic compounds of different classes by optimal descriptors.... |
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Impaired vitamin K recycling in uremia is rescued by vitamin K supplementation.
Kidney Int. 86(2) , 286-93, (2014) In chronic kidney disease, vitamin K-dependent proteins, including the calcification inhibitor matrix Gla protein, are largely uncarboxylated indicating that functional vitamin K deficiency may contribute to uremic vascular calcification. Since the effects of... |
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Intestinal scavenger receptors are involved in vitamin K1 absorption.
J. Biol. Chem. 289(44) , 30743-52, (2014) Vitamin K1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K1 was examined using Caco-2 TC-7 cell monolayers as a model of human intestinal epithelium and in... |
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Capillary electromigration techniques as tools for assessing the status of vitamins A, C and E in patients with cystic fibrosis.
J. Pharm. Biomed. Anal. 102 , 45-53, (2014) The purpose of this work is the evaluation of the nutritional status of patients with cystic fibrosis (CF), based on the level of vitamin C in urine and vitamins A and E in serum, using the fast, selective and fully automated micellar electrokinetic capillary... |
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Impact of nonsynonymous mutations of factor X on the functions of factor X and anticoagulant activity of edoxaban.
Blood Coagul. Fibrinolysis 26(2) , 117-22, (2015) Edoxaban is an oral direct factor Xa (FXa) inhibitor and its efficacy as an oral anticoagulant is less subject to drug-food and drug-drug interaction than existing vitamin K antagonists. Although this profile of edoxaban suggests it is well suited for clinica... |
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Lipid hydrolysis products affect the composition of infant gut microbial communities in vitro.
Br. J. Nutr. 114 , 63-74, (2015) Some lipid hydrolysis products such as medium-chained NEFA (MC-NEFA), sphingosine and monoacylglycerols (MAG) possess antibacterial activity, while others, including oleic acid, are essential for the optimal growth of Lactobacillus species. Thus, changes in t... |
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The hydrogen-bonded dianion of vitamin K1 produced in aqueous-organic solutions exists in equilibrium with its hydrogen-bonded semiquinone anion radical.
J. Phys. Chem. B 117(8) , 2396-402, (2013) When the quinone, vitamin K1 (VK1), is electrochemically reduced in aqueous-acetonitrile solutions (CH3CN with 7.22 M H2O), it undergoes a two-electron reduction to form the dianion that is hydrogen-bonded with water [VK1(H2O)y(2–)]. EPR and voltammetry exper... |
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Effect of phylloquinone (vitamin K1) supplementation for 12 months on the indices of vitamin K status and bone health in adult patients with Crohn's disease.
Br. J. Nutr. 112(7) , 1163-74, (2014) Although epidemiological findings support a role for vitamin K status in the improvement of bone indices in adult patients with Crohn's disease (CD), this needs to be confirmed in double-blind, randomised controlled trials (RCT) with phylloquinone (vitamin K1... |