Vitamin K1
Vitamin K1 structure
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Common Name | Vitamin K1 | ||
|---|---|---|---|---|
| CAS Number | 84-80-0 | Molecular Weight | 450.696 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 546.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C31H46O2 | Melting Point | −20 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 200.4±27.1 °C | |
Use of Vitamin K1Vitamin K1 a fat-soluble, naturally occurring vitamin required for blood coagulation and bone and vascular metabolism. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | phylloquinone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Vitamin K1 a fat-soluble, naturally occurring vitamin required for blood coagulation and bone and vascular metabolism. |
|---|---|
| Related Catalog | |
| In Vitro | Phylloquinone (Vitamin K1) is a prenylated naphthoquinone that is synthesized exclusively by plants, green algae, and some species of cyanobacteria, where it serves as a vital electron carrier in photosystem I and as an electron acceptor for the formation of protein disulfide bonds. In humans and other vertebrates, phylloquinone plays the role of a vitamin (vitamin K1) that is required for blood coagulation and bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil represents the major dietary source of vitamin K for humans[1]. Vitamin K1 treatment causes a significant antiproliferative effect and induces apoptosis in Caco-2, HT-29, and SW480 cell lines, with the involvement of the MAPK pathway. A concomitant and significant decrease in the polyamine biosynthesis occurr[2]. |
| In Vivo | Subjects who increase their dietary intake of vitamin K during the follow-up had a 51% reduced risk of incident diabetes compared with subjects who decrease or does not change the amount of phylloquinone intake[3]. Vitamin K supplementation reverses the high fat diet induced bone deterioration by modulating osteoblast and osteoclast activities and prevent bone loss in a high-fat diet-induced obese mice[4]. Application of vitamin K1 to the skin has been used for suppression of pigmentation and resolution of bruising. The effects produced by the topical vitamin K1 shows significant healing when compared with control group in parameters such as wound contraction, epithelialization period, hydroxyproline content and tensile strength[5]. |
| Cell Assay | Caco-2, HT-29, and SW480 cells are treated with increasing concentrations of vitamin K1 (10, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h. MTT is added to each dish and incubated for 2 h at 37°C. At the end of the incubation period, the medium is removed. The plate is read at 570 nM[2]. |
| Animal Admin | Rats: For inducing full-thickness wound in rats, the excisional wound model is used. Five groups consisting of 8 rats each are used. Vitamin K cream (1% and 2%, w/w) is prepared in eucerin base and applied on the wound once a day until complete healing had occurred. Healing is defined by decreased wound margin (wound contraction), re-epithelialization, tensile strength and hydroxyproline content. Histopathological examination is also done[5]. Mice: Four-week-old C57BL/6J male mice are fed a 10% fat normal diet group or a 45% kcal high-fat diet group, with or without 200 mg/1000 g vitamin K1 (Normal diet + K1, high-fat diet + K1) and 200 mg/1000 g vitamin K2 (Normal diet + K2, high-fat diet + K2) for 12 weeks[4]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 546.4±50.0 °C at 760 mmHg |
| Melting Point | −20 °C(lit.) |
| Molecular Formula | C31H46O2 |
| Molecular Weight | 450.696 |
| Flash Point | 200.4±27.1 °C |
| Exact Mass | 450.349792 |
| PSA | 34.14000 |
| LogP | 12.25 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.511 |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | QJ5800000 |
| HS Code | 2936290090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
|---|---|
| DownStream 3 | |
CAS#:31599-79-8
CAS#:75-24-1
CAS#:58-27-5
CAS#:150-86-7
CAS#:24529-80-4
CAS#:53170-97-1![(E/Z)-[2-Methyl-4-(2'-tetrahydropyranyloxy)-2-butenyl]chlorid Structure](https://image.chemsrc.com/caspic/495/55453-94-6.png)
CAS#:55453-94-6
CAS#:65527-95-9![Essigsaeure-[(E)-2-methyl-4-(3',4',5',6'-tetrahydro-2'H-pyran-2'-yl)oxy-2-butenyl]ester Structure](https://image.chemsrc.com/caspic/064/66432-56-2.png)
CAS#:66432-56-2
CAS#:502-69-2![[R-[R*,R*-(E)]]-2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-diol structure](https://image.chemsrc.com/caspic/364/572-96-3.png)
CAS#:572-96-3
CAS#:16869-68-4This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2936290090 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
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Rapid high performance liquid chromatography-high resolution mass spectrometry methodology for multiple prenol lipids analysis in zebrafish embryos.
J. Chromatogr. A. 1412 , 59-66, (2015) The analysis of lipid molecules in living organism is an important step in deciphering metabolic pathways. Recently, the zebrafish has been adopted as a valuable animal model system to perform in vivo... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ... |
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QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.
Eur. J. Med. Chem. 43 , 714-40, (2008) Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| KONAKION |
| Rac-Phytonadione-D7 |
| Phylloquinone-d3 |
| VITAMIN K1 (PHYTONADIONE) |
| Veda K1 |
| 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecen-1-yl]-1,4-naphthoquinone |
| Kephton |
| Antihemorrhagic vitamin |
| 2-METHYL-3-PHYTYL-1,4-NAPHTHOQUINONE |
| 2-methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione |
| 2',3'-trans-Vitamin K1 |
| AQUAMEPHYTON |
| Combinal K1 |
| Orakay |
| 2-méthyl-3-[(2E,7R,11R)-3,7,11,15-tétraméthylhexadéc-2-én-1-yl]naphtalène-1,4-dione |
| EINECS 201-564-2 |
| Vitamin K1 |
| Veta K1 |
| [R-[R*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione |
| VITAMIN K1-[2H7] (PHYTONADIONE) |
| Phyllochinonum |
| Phytonadione, K1 |
| VITAMIN K/PHYLLOQUINONE |
| phytomenadione |
| Kaywan |
| 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalen-1,4-dion |
| 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-naphthoquinone |
| 2-Methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione |
| Aqua mephyton |
| vitamin K1 quinone |
| Vitamin K1 (VAN) |
| Kativ N |
| K-Ject |
| VITAMIN K<SUBSCRIPT>1</SUBSCRIPT> |
| Synthex P |
| 2',3'-t |
| Phytylmenadione |
| kativn |
| Mono-kay |
| MFCD00214063 |
| PHYTONADIONE |
| Kinadion |
| Vitamin- K1 |
| Phylloquinone (8CI) |
| PHYTOMENADIONE, BP STANDARD |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of phylloquinone? |
| A: Molecular formula of phylloquinone is C31H46O2. |
| Q: What are the downstream products of phylloquinone? |
| A: Related downstream products(CAS) of phylloquinone: 502-69-2;572-96-3;16869-68-4. |
| Q: What is the safety information for phylloquinone? |
| A: Safety information for phylloquinone: 26-37/39. |
| Q: What is the melting point of phylloquinone? |
| A: Melting point of phylloquinone is −20 °C(lit.). |
| Q: What are the upstream materials of phylloquinone? |
| A: Related upstream materials(CAS) of phylloquinone: 31599-79-8;75-24-1;58-27-5;150-86-7;24529-80-4;53170-97-1;55453-94-6;65527-95-9;66432-56-2. |
| Q: What is the LogP of phylloquinone? |
| A: LogP of phylloquinone is 12.25. |
| Q: What is the molecular weight of phylloquinone? |
| A: Molecular weight of phylloquinone is 450.696. |
| Q: What is the polar surface area (PSA) of phylloquinone? |
| A: Polar surface area (PSA) of phylloquinone is 34.14000. |
| Q: What is the English name of phylloquinone? |
| A: The English name of phylloquinone is phylloquinone. |
| Q: What are the storage conditions for phylloquinone? |
| A: Storage conditions for phylloquinone: 2-8°C. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |