2-氯-1,3-丁二烯

Rev. Environ. Contam. Toxicol. 189 , 131-79, (2007)

The diene monomers, 1,3-butadiene, chloroprene, and isoprene, respectively, differ only in substitution of a hydrogen, a chlorine, or a methyl group at the second of the four unsaturated carbon atoms in these linear molecules. Literature reviewed in the prece...

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 889-890 , 69-76, (2012)

We developed and validated an analytical method for the simultaneous determination of several chlorine and non-chlorine containing mercapturic acids in urine as specific metabolites of the hazardous chemicals 2-chloroprene and epichlorohydrin. The method invo...

Chem. Biol. Interact. 166(1-3) , 352-9, (2007)

Mathematical models are increasingly being used to simulate events in the exposure-response continuum, and to support quantitative predictions of risks to human health. Physiologically based pharmacokinetic (PBPK) models address that portion of the continuum ...

Chem. Biol. Interact. 166(1-3) , 317-22, (2007)

The DuPont Company has maintained a mortality registry for all active and pensioned U.S. employees since 1957. Standardized mortality ratios (SMRs) for each plant site in the U.S. can be calculated based on the comparison with the entire U.S. DuPont populatio...

Chem. Biol. Interact. 166(1-3) , 323-31, (2007)

Chloroprene (2-chloro-1,3-butadiene, 1) is oxidised by cytochrome P450 enzymes in mammalian liver microsomes to several metabolites, some of which are reactive towards DNA and are mutagenic. Much less of the metabolite (1-chloroethenyl)oxirane (2a/2b) was for...

Chem. Biol. Interact. 166(1-3) , 341-51, (2007)

Beta-chloroprene (C(4)H(5)Cl, chloroprene, 2-chloro-1,3-butadiene, CASRN 126-99-8) is a volatile, flammable liquid monomer utilized primarily in the manufacture of neoprene (polychloroprene) elastomer used in belts, hoses, gloves, wire coatings, and tubing. A...

Lifetime Data Anal. 14(2) , 134-53, (2008)

We consider efficient estimation of regression and association parameters jointly for bivariate current status data with the marginal proportional hazards model. Current status data occur in many fields including demographical studies and tumorigenicity exper...

Biom. J. 50(3) , 364-74, (2008)

This paper discusses multivariate interval-censored failure time data that occur when there exist several correlated survival times of interest and only interval-censored data are available for each survival time. Such data occur in many fields. One is tumori...

Forensic Sci. Int. 215(1-3) , 110-3, (2012)

Objective Chloroprene, 2-chloro-1,3 butadiene, is a volatile synthetic liquid. The chloroprene monomer is extremely reactive and is used for the production of latexes and synthetic rubber such as Neoprene. Up to now an acute lethal human exposure has been des...

Arch. Environ. Contam. Toxicol. 54(1) , 1-8, (2008)

The performance of protective gloves against metalworking fluids (MWFs) has rarely been studied because of the difficult chemical analysis associated with complex MWFs. In the present study, glove swelling was used as a screening parameter of glove compatibil...