![]() 7-氨基头孢烷酸结构式
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常用名 | 7-氨基头孢烷酸 | 英文名 | 7-Aminocephalosporanic acid |
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CAS号 | 957-68-6 | 分子量 | 272.278 | |
密度 | 1.6±0.1 g/cm3 | 沸点 | 560.6±50.0 °C at 760 mmHg | |
分子式 | C10H12N2O5S | 熔点 | >300 °C(lit.) | |
MSDS | 中文版 美版 | 闪点 | 292.9±30.1 °C | |
符号 |
![]() GHS08 |
信号词 | Danger |
Construction of recombinant Escherichia coli D11/pMSTO and its use in enzymatic preparation of 7-aminocephalosporanic acid in one pot.
J. Biotechnol. 129(3) , 400-5, (2007) The main drawback in the industrial production of 7-aminocephalosporanic acid is the accumulation of intermediate (AKA-7-ACA) and destruction of substrate (cephalosporin C) catalyzed by catalase and beta-lactamase. To overcome the adverse effect of these enzy... |
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Batch production of deacetyl 7-aminocephalosporanic acid by immobilized cephalosporin-C deacetylase.
Appl. Microbiol. Biotechnol. 65(3) , 263-7, (2004) Bacillus subtilis SHS0133 cephalosporin-C deacetylase (CAH) overexpressed in Escherichia coli was immobilized on an anion-exchange resin, KA-890, using glutaraldehyde. The activity yield of immobilized enzyme was approximately 55% of the free enzyme. The pH r... |
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Site-specific protonation microequilibria of penicillin and cephalosporin beta-lactam core molecules.
Eur. J. Pharm. Sci. 32(1) , 1-7, (2007) Acid-base chemistry of 6-aminopenicillanic acid (6-APA) and 7-aminocephalosporanic acid (7-ACA), the fundamental units of the two classical antibiotic families is characterised at the macroscopic and microscopic levels. (1)H NMR-pH and pH-potentiometric titra... |
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A single Phe54Tyr substitution improves the catalytic activity and thermostability of Trigonopsis variabilis D-amino acid oxidase.
New Biotechnology 27(1) , 78-84, (2010) The industrial importance of Trigonopsis variabilisd-amino acid oxidase (TvDAAO) is represented by its biocatalytic oxidative deamination of cephalosporin C (CPC) to yield glutaryl-7-aminocephalosporanic acid (GL-7-ACA). The process has been incorporated into... |
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Double knockout of β-lactamase and cephalosporin acetyl esterase genes from Escherichia coli reduces cephalosporin C decomposition.
J. Biosci. Bioeng. 113(6) , 737-41, (2012) The phenomenon of CPC decomposition occurs in Escherichia coli JM105/pMKC-sCPCacy during the one-step enzymatic conversion of cephalosporin C (CPC) into 7-aminocephalosporanic acid (7-ACA) by CPC acylase (sCPCAcy) for synthesis of cephalosporin antibiotics. E... |
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Construction and application of fusion proteins of D-amino acid oxidase and glutaryl-7-aminocephalosporanic acid acylase for direct bioconversion of cephalosporin C to 7-aminocephalosporanic acid.
Biotechnol. Lett. 26(11) , 939-45, (2004) Two fusion proteins of D-amino acid oxidase (DAAO) and glutaryl-7-aminocephalosporanic acid acylase (GLA) were designed to simplify the bioconversion process of cephalosporin C to 7-aminocephalosporanic acid (7-ACA), which is conventionally produced in a two-... |
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Single-step conversion of cephalosporin-C to 7-aminocephalosporanic acid by free and immobilized cells of Pseudomonas diminuta.
Appl. Biochem. Biotechnol. 126(1) , 13-21, (2005) 7-Aminocephalosporanic acid (7-ACA), the starting material for the production of a number of clinically used semisynthetic cephalosporins, is produced by deacylation of cephalosporin-C. The production of 7-ACA was studied in various modes, at the optimal cond... |
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Struvite precipitation for ammonia nitrogen removal in 7-aminocephalosporanic acid wastewater.
Molecules 17(2) , 2126-39, (2012) 7-Aminocephalosporanic acid wastewater usually contains high concentrations of ammonium (NH₄⁺-N), which is known to inhibit nitrification during biological treatment processes. Chemical precipitation is a useful technology to remove ammonium from wastewater. ... |
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Reusability of entrapped cells of Pseudomonas diminuta for production of 7-aminocephalosporanic acid.
Appl. Biochem. Biotechnol. 141(1) , 119-26, (2007) Entrapped cells of P. diminuta were used for the production of 7-aminocephalosporanic acid (7-ACA), a key intermediate required for the production of most of the clinically used cephalosporin derivatives, i.e., semisynthetic cephalosporins. The repeated batch... |
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Environmentally safe production of 7-ACA by recombinant Acremonium chrysogenum.
Curr. Microbiol. 61(6) , 609-14, (2010) 7-Amino cephalosporanic acid (7-ACA), which is currently obtained by chemical deacylation from cephalosporin C (CPC), is a major intermediate for industrial production of β-lactam antibiotics. 7-ACA can also be produced from CPC by enzymatic route including t... |