丝裂霉素C结构式
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常用名 | 丝裂霉素C | 英文名 | Mitomycin C |
|---|---|---|---|---|
| CAS号 | 50-07-7 | 分子量 | 334.327 | |
| 密度 | 1.9±0.1 g/cm3 | 沸点 | 532.0±60.0 °C at 760 mmHg | |
| 分子式 | C15H18N4O5 | 熔点 | 360 °C | |
| MSDS | 中文版 美版 | 闪点 | 275.5±32.9 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.
J. Cell Biol. 206(2) , 183-97, (2014) Deoxyribonucleic acid (DNA) lesions encountered during replication are often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow for completion of DNA replication. Rad18 is a central E3 ubiquitin ligase in DDT, which ... |
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Sodium fluoride promotes apoptosis by generation of reactive oxygen species in human lymphocytes.
J. Toxicol. Environ. Health A 77(21) , 1269-80, (2014) Fluoride generated the attention of toxicologists due to its deleterious effects at high concentrations in human populations suffering from fluorosis and with in vivo experimental models. Interest in its undesirable effects has resurfaced due to the awareness... |
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Piperine inhibits the growth and motility of triple-negative breast cancer cells.
Cancer Lett. 357(1) , 129-40, (2014) Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC ... |
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Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.
Mol. Cancer Ther. 14 , 865-76, (2015) WEE1 kinase regulates CDK1 and CDK2 activity to facilitate DNA replication during S-phase and to prevent unscheduled entry into mitosis. WEE1 inhibitors synergize with DNA-damaging agents that arrest cells in S-phase by triggering direct mitotic entry without... |
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Fluorescent mixed ligand copper(II) complexes of anthracene-appended Schiff bases: studies on DNA binding, nuclease activity and cytotoxicity.
Dalton Trans. 44 , 11997-2010, (2015) A series of mixed ligand copper(ii) complexes of the type [Cu(L)(phen)(ACN)](ClO4)21-5, where L is a bidentate Schiff base ligand (N(1)-(anthracen-10-ylmethylene)-N(2)-methylethane-1,2-diamine (L1), N(1)-(anthracen-10-ylmethylene)-N(2),N(2)-dimethylethane-1,2... |
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Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.
J. Inorg. Biochem. 140 , 94-103, (2014) In the present study we have synthesized a novel amphiphilic porphyrin and its Ag(II) complex through modification of water-soluble porphyrinic structure in order to increase its lipophilicity and in turn pharmacological potency. New cationic non-symmetrical ... |
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In vitro toxicological assessment of iron oxide, aluminium oxide and copper nanoparticles in prokaryotic and eukaryotic cell types.
Drug Chem. Toxicol. 38 , 152-61, (2015) Metallic nanoparticles (NPs) have a variety of applications in different industries including pharmaceutical industry where these NPs are used mainly for image analysis and drug delivery. The increasing interest in nanotechnology is largely associated with un... |
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Evaluation of eight reference genes for quantitative polymerase chain reaction analysis in human T lymphocytes co‑cultured with mesenchymal stem cells.
Mol. Med. Report. 12 , 7721-7, (2015) Accurate gene expression analysis relies on the selection of a stable reference gene, as unstable reference genes can alter experimental results and conclusions. It is widely‑accepted that reference genes exhibit different expression levels in different types... |
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Low doses of ochratoxin A induce micronucleus formation and delay DNA repair in human lymphocytes.
Food Chem. Toxicol. 74 , 249-54, (2015) The contamination of food commodities by fungal toxins has attracted great interest because many of these mycotoxins are responsible for different diseases, including cancer and other chronic illnesses. Ochratoxin A (OTA) is a mycotoxin naturally present in f... |
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miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18.
Age (Dordr.) 36(6) , 9724, (2014) Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging... |