盐酸卤泛群
盐酸卤泛群结构式
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常用名 | 盐酸卤泛群 | 英文名 | Halofantrine hydrochloride |
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| CAS号 | 36167-63-2 | 分子量 | 536.885 | |
| 密度 | 1.244g/cm3 | 沸点 | 596.2ºC at 760mmHg | |
| 分子式 | C26H31Cl3F3NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 314.4ºC |
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Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
Chirality 24(7) , 558-65, (2012) Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the effect of hyperlipidemic (HL) serum ... |
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Discordant temporal evolution of Pfcrt and Pfmdr1 genotypes and Plasmodium falciparum in vitro drug susceptibility to 4-aminoquinolines after drug policy change in French Guiana.
Antimicrob. Agents Chemother. 56(3) , 1382-9, (2012) Analysis of the evolution of drug target genes under changing drug policy is needed to assist monitoring of Plasmodium falciparum drug resistance in the field. Here we genotype Pfcrt and Pfdmr1 of 700 isolates collected in French Guiana from 2000 (5 years aft... |
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Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful.
Eur. J. Pharm. Sci. 47(2) , 347-51, (2012) The purpose of this study was to evaluate if a rat model, based upon co-administration of the anion-exchanging resin, cholestyramine, could replace surgery when evaluating the importance of bile on drug absorption. Two different formulations were used for the... |
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Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria.
J. Pharm. Pharmacol. 64(11) , 1603-13, (2012) To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria.Healthy volunteer data were obtained from six volunteers who received three different doses of HF (250,... |
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CDA: combinatorial drug discovery using transcriptional response modules.
PLoS ONE 7(8) , e42573, (2012) Anticancer therapies that target single signal transduction pathways often fail to prevent proliferation of cancer cells because of overlapping functions and cross-talk between different signaling pathways. Recent research has identified that balanced multi-c... |
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Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.
Mol. Pharm. 8(4) , 1132-9, (2011) Elevated systemic levels of triglyceride-rich lipoproteins (TRL) are a risk factor for the development of atherosclerosis. In patients with metabolic syndrome (MetS), intestinal TRL overproduction contributes to high systemic TRL levels, and recent studies su... |
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In vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, quinine, mefloquine and halofantrine in Abidjan (Côte d'Ivoire).
Afr. Health Sci. 10(2) , 111-6, (2010) Malaria is the primary cause of hospitalization in Côte d'Ivoire. Early treatment is one of the strategies to control this illness. However, the spread of resistance of Plasmodium falciparum to antimalarial drugs can seriously compromise this strategy.The aim... |
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Structural analysis of the antimalarial drug halofantrine by means of Raman spectroscopy and density functional theory calculations.
J. Biomed. Opt. 15(4) , 041516, (2010) The structure of the antimalarial drug halofantrine is analyzed by means of density functional theory (DFT) calculations, IR, and Raman spectroscopy. Strong, selective enhancements of the Raman bands of halofantrine at 1621 and 1590 cm(-1) are discovered by m... |
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Effects of anti-malarial drugs on the electrocardiographic QT interval modelled in the isolated perfused guinea pig heart system.
Malaria Journal 9 , 318, (2010) Concern over the potential cardiotoxicity of anti-malarial drugs inducing a prolonged electrocardiographic QT interval has resulted in the almost complete withdrawal from the market of one anti-malarial drug - halofantrine. The effects on the QT interval of f... |
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In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug: halofantrine.
Asian Pac. J. Trop. Med. 4(4) , 253-8, (2011) To formulate and evaluate in vitro, surface-modified solid lipid microspheres containing halofantrine using lipid matrix formed from goat fat and a phospholipid (P90H).The model drug, halofantrine in an increasing concentration of 1%, 2%, 3%, 4% and 5% w/w wa... |