米替福新结构式
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常用名 | 米替福新 | 英文名 | Miltefosine |
|---|---|---|---|---|
| CAS号 | 58066-85-6 | 分子量 | 407.568 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C21H46NO4P | 熔点 | 232-234ºC | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Alkylphosphocholines and curcumin induce programmed cell death in cutaneous T-cell lymphoma cell lines.
Leuk. Res. 38(1) , 49-56, (2014) While most patients with early-stage cutaneous T-cell lymphomas (CTCL) have a very good prognosis, the survival of patients with extensive tumour stage and visceral involvement remains extremely poor and necessitates the development of more effective treatmen... |
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In vitro drug susceptibility of Leishmania infantum isolated from humans and dogs.
Exp. Parasitol. 135(1) , 36-41, (2013) Visceral leishmaniasis (VL) caused by parasites of Leishmania donovani complex is a severe human disease which often leads to death if left untreated. Domestic dogs are the main reservoir hosts for zoonotic human visceral infection caused by Leishmania infant... |
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Bis-benzimidazole hits against Naegleria fowleri discovered with new high-throughput screens.
Antimicrob. Agents Chemother. 59 , 2037-44, (2015) Naegleria fowleri is a pathogenic free-living amoeba (FLA) that causes an acute fatal disease known as primary amoebic meningoencephalitis (PAM). The major problem for infections with any pathogenic FLA is a lack of effective therapeutics, since PAM has a cas... |
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Quantification of miltefosine in peripheral blood mononuclear cells by high-performance liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 998-999 , 57-62, (2015) Phagocytes, the physiological compartment in which Leishmania parasites reside, are the main site of action of the drug miltefosine, but the intracellular pharmacokinetics of miltefosine remain unexplored. We developed a bioanalytical method to quantify milte... |
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High selective antileishmanial activity of vanadium complex with stilbene derivative.
Acta Trop. 148 , 120-7, (2015) Leishmaniasis is a group of disease caused by different species of the parasite Leishmania affecting millions of people worldwide. Conventional therapy relies on multiple parenteral injections with pentavalent antimonials which exhibit high toxicity and vario... |
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Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli.
Bioorg. Med. Chem. 15 , 6834-45, (2007) The type II fatty acid pathway (FAS-II) is a validated target for antimicrobial drug discovery. An activity-guided isolation procedure based on Plasmodium falciparum enoyl-ACP reductase (PfFabI) enzyme inhibition assay on the n-hexane-, the CHCl(3-) and the a... |
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Searching for new cures for tuberculosis: design, synthesis, and biological evaluation of 2-methylbenzothiazoles.
J. Med. Chem. 52 , 6757-67, (2009) The actual development and clinical use of new therapeutics for tuberculosis (TB) have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6 mo... |
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Novel arylimidamides for treatment of visceral leishmaniasis.
Antimicrob. Agents Chemother. 54 , 2507-16, (2010) Arylimidamides (AIAs) represent a new class of molecules that exhibit potent antileishmanial activity (50% inhibitory concentration [IC(50)], <1 microM) against both Leishmania donovani axenic amastigotes and intracellular Leishmania, the causative agent for ... |
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2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stagePlasmodiuminfections
Bioorg. Med. Chem. 18 , 7475-85, (2010) 2-, 5-, 6-, and 9-hexadecynoic acids (HDAs) were synthesized and evaluated in vitro against various parasitic protozoa. 2-HDA inhibited both liver and blood stage Plasmodium infections and multiple plasmodial FAS-II target enzymes. 2-HDA was further studied t... |