组胺
组胺结构式
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常用名 | 组胺 | 英文名 | Histamine |
|---|---|---|---|---|
| CAS号 | 51-45-6 | 分子量 | 111.145 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 331.0±17.0 °C at 760 mmHg | |
| 分子式 | C5H9N3 | 熔点 | 83-84ºC | |
| MSDS | 中文版 美版 | 闪点 | 180.3±8.1 °C | |
| 符号 |
GHS06, GHS08 |
信号词 | Danger |
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Clonal differences in IgE antibodies affect cutaneous anaphylaxis-associated thermal sensitivity in mice.
Immunol. Lett. 162(1 Pt A) , 149-58, (2014) Cellular and molecular mediators of immune responses are increasingly implicated in acute and chronic pain pathophysiologies. Here we demonstrate that passive cutaneous IgE/Ag anaphylaxis provokes increased thermal sensitivity in the hind paw tissue of mice. ... |
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Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.
Biochem. Biophys. Res. Commun. 463 , 434-9, (2015) Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechanisms in the development of skin fibrosis remain largely unc... |
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Inhibition of TRPM7 channels reduces degranulation and release of cytokines in rat bone marrow-derived mast cells.
Int. J. Mol. Sci. 15(7) , 11817-31, (2014) mast cells play an important role in airway inflammation in asthma. The transient receptor potential melastatin-like 7 (TRPM7) channel is expressed in primary human lung mast cells and plays a critical role for cell survival. This study aimed to investigate t... |
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Histamine H4 receptor as a new therapeutic target for choroidal neovascularization in age-related macular degeneration.
Br. J. Pharmacol. 171(15) , 3754-63, (2014) The present treatment for choroidal neovascularization (CNV) associated with age-related macular degeneration (AMD) is not sufficient. Hence, we examined the therapeutic efficacy of reducing histamine H4 receptor expression on CNV in mice.H4 receptor expressi... |
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Prevalence and Characterization of High Histamine-Producing Bacteria in Gulf of Mexico Fish Species.
J. Food Prot. 78 , 1335-42, (2015) Recent developments in detection and enumeration of histamine-producing bacteria (HPB) have created powerful molecular-based tools to better understand the presence of spoilage bacteria and conditions, resulting in increased risk of scombrotoxin fish poisonin... |
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Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.
J. Pharmacol. Exp. Ther. 350(3) , 589-604, (2014) Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel drug candidate in clinical development for psychiatric disorders with high affinity for serotonin, dopamine, and noradrenaline receptors. In particula... |
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The mast cell stabilizer sodium cromoglycate reduces histamine release and status epilepticus-induced neuronal damage in the rat hippocampus.
Neuropharmacology 92 , 49-55, (2015) Experiments were designed to evaluate changes in the histamine release, mast cell number and neuronal damage in hippocampus induced by status epilepticus. We also evaluated if sodium cromoglycate, a stabilizer of mast cells with a possible stabilizing effect ... |
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Enhanced Indirect Photochemical Transformation of Histidine and Histamine through Association with Chromophoric Dissolved Organic Matter.
Environ. Sci. Technol. 49 , 5511-9, (2015) Photochemical transformations greatly affect the stability and fate of amino acids (AAs) in sunlit aquatic ecosystems. Whereas the direct phototransformation of dissolved AAs is well investigated, their indirect photolysis in the presence of chromophoric diss... |
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Use of Commercial Dry Yeast Products Rich in Mannoproteins for White and Rosé Sparkling Wine Elaboration.
J. Agric. Food Chem. 63 , 5670-81, (2015) In sparkling wines, mannoproteins released during yeast autolysis largely affect their final quality. This process is very slow and may take several months. The aim of this work was to study the effect of several commercial dry yeast autolysates on the chemic... |
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Development and validation of a liquid-chromatography tandem mass spectrometry method to determine in vitro and in vivo histamine release.
J. Pharm. Biomed. Anal. 102 , 494-9, (2015) Histamine is an important biogenic amine involved in regulating numerous physiological and pathophysiological processes in humans and animals. To date, there have been very few studies focused on developing and validating sensitive liquid-chromatography-tande... |