溴哌利多
溴哌利多结构式
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常用名 | 溴哌利多 | 英文名 | Bromperidol |
|---|---|---|---|---|
| CAS号 | 10457-90-6 | 分子量 | 420.31500 | |
| 密度 | 1.366 g/cm3 | 沸点 | 543.6ºC at 760 mmHg | |
| 分子式 | C21H23BrFNO2 | 熔点 | 156-158ºC | |
| MSDS | N/A | 闪点 | 282.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Sensitive determination of 4-(4-bromophenyl)-4-hydroxypiperidine, a metabolite of bromperidol, in rat plasma by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
Biol. Pharm. Bull. 29(12) , 2479-82, (2006) The purpose of this study was to determine the level of 4-(4-bromophenyl)-4-hydroxypiperidine (BPHP), a bromperidol (BRO) metabolite, in rat plasma by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole... |
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Folie à deux: double case-report of shared delusions with a fatal outcome.
Clin. Ter. 162(1) , 45-9, (2011) Treatment of shared delusional disorder (folie à deux) often involves separation and use of antipsychotic medication, with uncertain outcomes and potential risks.We report on two highly interdependent and chronically psychotic sisters with shared systematic d... |
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Comparison of the anti-dopamine D₂ and anti-serotonin 5-HT(2A) activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof.
J. Psychopharmacol. 27(4) , 396-400, (2013) Second-generation antipsychotics, which have become the standard drug therapies for schizophrenia, are known to have a serotonin 5-HT(2A) receptor blocking effect in addition to a dopamine D₂ receptor blocking effect. However, although chlorpromazine (CPZ) ha... |
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Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.
Antimicrob. Agents Chemother. 55(8) , 3861-9, (2011) Therapeutic options for tuberculosis (TB) are limited and notoriously ineffective despite the wide variety of potent antibiotics available for treating other bacterial infections. We investigated an approach that enables an expansion of TB therapeutic strateg... |
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Lesioning the thalamus for dyskinesia.
Stereotact. Funct. Neurosurg. 77(1-4) , 33-9, (2001) Recent advances on understanding the pallidothalamic relation lead us to perform Vim-Vo thalamotomy (combined thalamic lesion in ventralis intermedius nucleus and ventralis oralis nucleus) for cases with dyskinesia. In our recent series of thalamotomies, ther... |
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Comparison of prolactin concentrations between haloperidol and bromperidol treatments in schizophrenic patients.
Prog. Neuropsychopharmacol. Biol. Psychiatry 26 , 575-578, (2002) The antipsychotic drug, bromperidol, is a close structural analogue of haloperidol. These two drugs also have similarities in metabolic pathways and pharmacological properties. In the present study, the prolactin concentrations in plasma during bromperidol ve... |
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Switching to amisulpride due to hepatic complications.
Eur. Psychiatry 17(3) , 170-1, (2002)
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Establishment of new cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol.
Ther. Drug Monit. 26(3) , 336-41, (2004) The authors have developed and verified the precision and accuracy of new automated cloned enzyme donor immunoassays (CEDIA) for haloperidol and bromperidol, and cross-validations have been performed with conventional semiautomated EIA kits (MARKIT-M) and hig... |
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Poor reliability of therapeutic drug monitoring data for haloperidol and bromperidol using enzyme immunoassay.
Ther. Drug Monit. 25(6) , 709-14, (2003) Therapeutic drug monitoring (TDM) services for plasma concentrations of haloperidol and bromperidol using enzyme immunoassay (EIA) methods are available in Japan, whereas high-performance liquid chromatographic (HPLC) methods are preferred in other countries.... |