1-(3-氯苯基)双胍盐酸盐
1-(3-氯苯基)双胍盐酸盐结构式
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常用名 | 1-(3-氯苯基)双胍盐酸盐 | 英文名 | 1-(3-chlorophenyl)biguanide hydrochloride |
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| CAS号 | 2113-05-5 | 分子量 | 248.11 | |
| 密度 | 1.49g/cm3 | 沸点 | 434.1ºC at 760mmHg | |
| 分子式 | C8H11Cl2N5 | 熔点 | 190-194 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 216.3ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Serotonin modulates glutamatergic transmission to neurons in the lateral habenula.
Sci. Rep. 6 , 23798, (2016) The lateral habenula (LHb) is bilaterally connected with serotoninergic raphe nuclei, and expresses high density of serotonin receptors. However, actions of serotonin on the excitatory synaptic transmission to LHb neurons have not been thoroughly investigated... |
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5-HT3 receptor-dependent modulation of respiratory burst frequency, regularity, and episodicity in isolated adult turtle brainstems.
Respir. Physiol. Neurobiol. 172(1-2) , 42-52, (2010) To determine the role of central serotonin 5-HT(3) receptors in respiratory motor control, respiratory motor bursts were recorded from hypoglossal (XII) nerve rootlets on isolated adult turtle brainstems during bath-application of 5-HT(3) receptor agonists an... |
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Aggression and anxiety in adolescent AAS-treated hamsters: A role for 5HT3 receptors.
Pharmacol. Biochem. Behav. 134 , 85-91, (2015) Previously, we have shown that anabolic androgenic steroid (AAS) exposure throughout adolescence stimulates offensive aggression while also reducing anxious behaviors during the exposure period. Interestingly, AAS exposure through development correlates with ... |
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Inhibitory effect of ramosetron on corticotropin releasing factor- and soybean oil-induced delays in gastric emptying in rats.
J. Gastroenterol. Hepatol. 27(9) , 1505-11, (2012) Symptoms of functional dyspepsia (FD) are highly prevalent in patients with irritable bowel syndrome (IBS). However, the effects of therapeutic agents for IBS on the pathophysiology of FD are unclear. In this study, therefore, we examined the effects of ramos... |
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Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons.
BMC Neurosci. 13 , 10, (2012) The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons.5-HT (0.1, 1 mM) showed Na+/K+ pump current (Ip) densities of 0.40 ± 0.04, 0.34 ± 0.03 pA/pF contrast to 0... |
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Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex.
J. Neurosci. 32(40) , 13709-17, (2012) A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisit... |
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The role of 5-HT3receptors in the additive anticonvulsant effects of citalopram and morphine on pentylenetetrazole-induced clonic seizures in mice
Epilepsy Behav. 21(2) , 122-7, (2011) Citalopram, a selective serotonin reuptake inhibitor (SSRI), is frequently used in the treatment of major depressive disorders. In addition to its antidepressant features, citalopram shows some anticonvulsive properties at lower doses, whereas higher doses, i... |
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5-HT(3) receptor mediates the dose-dependent effects of citalopram on pentylenetetrazole-induced clonic seizure in mice: involvement of nitric oxide.
Epilepsy Res. 101(3) , 217-27, (2012) Citalopram is a selective serotonin reuptake inhibitor (SSRI), widely used in the treatment of depressive disorders. It has been shown that citalopram affects seizure susceptibility. Although the exact mechanism of these effects are not yet fully understood, ... |