4-氟-N-甲基苯胺
4-氟-N-甲基苯胺结构式
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常用名 | 4-氟-N-甲基苯胺 | 英文名 | 4-Fluoro-N-methylaniline |
|---|---|---|---|---|
| CAS号 | 459-59-6 | 分子量 | 125.14400 | |
| 密度 | 1.1057 | 沸点 | 79-80ºC(10 torr) | |
| 分子式 | C7H8FN | 熔点 | 79-80°C | |
| MSDS | 中文版 美版 | 闪点 | 75ºC | |
| 符号 |
GHS05, GHS06 |
信号词 | Danger |
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Role of cytochromes P-450 and flavin-containing monooxygenase in the biotransformation of 4-fluoro-N-methylaniline.
Drug Metab. Dispos. 21(2) , 218-30, (1993) In vivo and in vitro biotransformation of secondary aromatic amines was investigated using 4-fluoro-N-methylaniline as the model compound. Attention was focused on the role of cytochromes P-450 and the flavin-containing monooxygenase in formation of the vario... |
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Formation of a quinoneimine intermediate of 4-fluoro-N-methylaniline by FMO1: carbon oxidation plus defluorination.
Chem. Res. Toxicol. 23(5) , 861-3, (2010) Here, we report on the mechanism by which flavin-containing monooxygenase 1 (FMO1) mediates the formation of a reactive intermediate of 4-fluoro-N-methylaniline. FMO1 catalyzed a carbon oxidation reaction coupled with defluorination that led to the formation ... |
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