去氢表雄酮
去氢表雄酮结构式
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常用名 | 去氢表雄酮 | 英文名 | Dehydroepiandrosterone |
|---|---|---|---|---|
| CAS号 | 53-43-0 | 分子量 | 288.424 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 426.7±45.0 °C at 760 mmHg | |
| 分子式 | C19H28O2 | 熔点 | 146-151ºC | |
| MSDS | 中文版 美版 | 闪点 | 182.1±21.3 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation.
Biochem. Pharmacol. 90(3) , 288-96, (2014) Inhibition of 17α-hydroxylase/17,20-lyase (CYP17), which dictates the proceeding of androgen biosynthesis, is recommended as an effective treatment for androgen-dependent diseases. However, androgen depletion by selective CYP17 inhibition is accompanied with ... |
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Mechanistic Scrutiny Identifies a Kinetic Role for Cytochrome b5 Regulation of Human Cytochrome P450c17 (CYP17A1, P450 17A1).
PLoS ONE 10 , e0141252, (2015) Cytochrome P450c17 (P450 17A1, CYP17A1) is a critical enzyme in the synthesis of androgens and is now a target enzyme for the treatment of prostate cancer. Cytochrome P450c17 can exhibit either one or two physiological enzymatic activities differentially regu... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro
J. Steroid Biochem. Mol. Biol. 144 Pt B , 436-44, (2014) • Dutasteride and abiraterone were evaluated for inhibition of steroidogenesis. • Bypass mechanisms arise in the presence of abiraterone to form DHT. • Dutasteride inhibits T and DHT effectively in vitro. • Abiraterone inhibits AR and steroidogenesis leading ... |
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Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo.
J. Steroid Biochem. Mol. Biol. 143 , 19-28, (2014) Castration-resistant prostate cancer (CRPC) remains largely dependent on androgen receptor (AR). Residual tissue androgens are consistently detected within CRPC tumors and play a critical role in facilitating AR-mediated signaling pathways which lead to disea... |
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Identification of CYP3A7 for glyburide metabolism in human fetal livers.
Biochem. Pharmacol. 92(4) , 690-700, (2014) Glyburide is commonly prescribed for the treatment of gestational diabetes mellitus; however, fetal exposure to glyburide is not well understood and may have short- and long-term consequences for the health of the child. Glyburide can cross the placenta; feta... |
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Extending an in vitro panel for estrogenicity testing: the added value of bioassays for measuring antiandrogenic activities and effects on steroidogenesis.
Toxicol. Sci. 141(1) , 78-89, (2014) In the present study, a previously established integrated testing strategy (ITS) for in vitro estrogenicity testing was extended with additional in vitro assays in order to broaden its sensitivity to different modes of action resulting in apparent estrogenici... |
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An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.
J. Med. Chem. 51 , 2047-56, (2008) A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data set by adding a number of nonsteroidal SHBG ligands identifi... |
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Determination of steroid hormones in human plasma by GC-triple quadrupole MS.
Steroids 99 , 151-4, (2015) A fast and sensitive GC-MS/MS method is proposed to determine pregnenolone, dehydroepiandrosterone (DHEA), testosterone and dihydrotestosterone from human plasma. Steroids were extracted by liquid/liquid extraction, and derivatized with N-methyl-N-trimethylsi... |
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Anabolic steroids detected in bodybuilding dietary supplements - a significant risk to public health.
Drug Test. Anal. 7 , 609-18, (2015) Twenty-four products suspected of containing anabolic steroids and sold in fitness equipment shops in the United Kingdom (UK) were analyzed for their qualitative and semi-quantitative content using full scan gas chromatography-mass spectrometry (GC-MS), accur... |