三氮菌素 C
三氮菌素 C结构式
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常用名 | 三氮菌素 C | 英文名 | Triacsin C from Streptomyces sp. |
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| CAS号 | 76896-80-5 | 分子量 | 207.272 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 320.7±45.0 °C at 760 mmHg | |
| 分子式 | C11H17N3O | 熔点 | 100-102ºC | |
| MSDS | 美版 | 闪点 | 147.7±28.7 °C |
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Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide.
Cancer Sci. 100(8) , 1556-62, (2009) Lipid metabolism is often elevated in cancer cells and plays an important role in their growth and malignancy. Acyl-CoA synthetase (ACS), which converts long-chain fatty acids to acyl-CoA, is overexpressed in various types of cancer. However, the role of ACS ... |
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Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C.
World J. Gastroenterol. 17(44) , 4883-9, (2011) To investigate whether human acyl-CoA synthetase 5 (ACSL5) is sensitive to the ACSL inhibitor triacsin C.The ACSL isoforms ACSL1 and ACSL5 from rat as well as human ACSL5 were cloned and recombinantly expressed as 6xHis-tagged enzymes. Ni(2+)-affinity purifie... |
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Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization.
J. Thorac. Cardiovasc. Surg. 284 , 30941-8, (2009) Fatty acid-induced triacylglycerol synthesis produces triacylglycerol droplets with a protein coat that includes perilipin 3/TIP47 and perilipin 4/S3-12. This study addresses the following two questions. Where do lipid droplets emerge, and how are their coat ... |
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Selective and potent in vitro antimalarial activities found in four microbial metabolites.
J. Antibiot. 60(3) , 220-2, (2007) Antimalarial activities have been identified in four microbial metabolites through a screening programme of existing compounds in the Kitasato Institute chemical library. Hedamycin showed selective and potent activity against both drug-resistant and drug-sens... |
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Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes.
Am. J. Physiol. Endocrinol. Metab. 301(1) , E122-31, (2011) β-Adrenergic receptor (β-AR) activation elevates cAMP levels in fat cells and triggers both metabolic and transcriptional responses; however, the potential interactions between these pathways are poorly understood. This study investigated whether lipolysis af... |
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Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases.
J. Infect. Dis. 209(8) , 1279-87, (2014) Cryptosporidium is emerging as 1 of the 4 leading diarrheal pathogens in children in developing countries. Its infections in patients with AIDS can be fatal, whereas fully effective treatments are unavailable. The major goal of this study is to explore parasi... |
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Effects of fatty acids on angiogenic activity in the placental extravillious trophoblast cells.
Prostaglandins Leukot. Essent. Fatty Acids 88(2) , 155-62, (2013) Fatty acids regulate angiogenesis although no such information is available in first trimester placental trophoblast cells despite the fact that angiogenesis is a critical step involving these cells in early placentation. We investigated effects of different ... |
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Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: role of cardiolipin remodeling.
FEBS Lett. 586(3) , 235-41, (2012) Peroxidation of cardiolipin in mitochondria is essential for the execution of apoptosis. We suggested that integration of oleic acid into cardiolipin generates non-oxidizable cardiolipin species hence protects cells against apoptosis. We synthesized mitochond... |
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SREBP1 is required for the induction by glucose of pancreatic beta-cell genes involved in glucose sensing.
J. Lipid Res. 49(4) , 814-22, (2008) Previous studies have reported both positive and negative effects of culture of islets at high glucose concentrations on regulated insulin secretion. Here, we have reexamined this question in mouse islets and determined the role of changes in lipid synthesis ... |
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ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells.
J. Cell. Biochem. 112(3) , 881-93, (2011) The endoplasmic reticulum (ER) is essential for lipid biosynthesis, and stress signals in this organelle are thought to alter lipid metabolism. Elucidating the mechanisms that underlie the dysregulation of lipid metabolism in hepatocytes may lead to novel the... |