甲基丁香酚, 甲基丁子香酚
甲基丁香酚, 甲基丁子香酚结构式
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常用名 | 甲基丁香酚, 甲基丁子香酚 | 英文名 | Methyleugenol |
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| CAS号 | 93-15-2 | 分子量 | 178.228 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 254.7±0.0 °C at 760 mmHg | |
| 分子式 | C11H14O2 | 熔点 | −4 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 87.1±22.7 °C | |
| 符号 |
GHS07, GHS08, GHS09 |
信号词 | Warning |
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The natural basil flavonoid nevadensin protects against a methyleugenol-induced marker of hepatocarcinogenicity in male F344 rat.
Food Chem. Toxicol. 74 , 28-34, (2014) The alkenylbenzene methyleugenol occurs naturally in a variety of spices and herbs, including basil, and their essential oils. At high dose levels methyleugenol induces hepatocarcinogenicity in rodents following bioactivation to 1'-sulfooxymethyleugenol which... |
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Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations.
Toxicol. Appl. Pharmacol. 283(2) , 117-26, (2015) The present study aims at predicting the level of formation of the ultimate carcinogenic metabolite of methyleugenol, 1'-sulfooxymethyleugenol, in the human population by taking variability in key bioactivation and detoxification reactions into account using ... |
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Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages.
Bioorg. Med. Chem. Lett. 15 , 1949-53, (2005) 1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga inhibited nitric oxide (NO) production in lipopolysaccharide-activated mouse peritoneal macrophages with an IC(50) value of 2.3 microM. To clarify the structure-activity relationship of 1'S-1... |
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Methyl eugenol: its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination.
J. Insect Sci. 12 , 56, (2012) This review discusses the occurrence and distribution (within a plant) of methyl eugenol in different plant species (> 450) from 80 families spanning many plant orders, as well as various roles this chemical plays in nature, especially in the interactions bet... |
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Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole.
Food Chem. Toxicol. 40(7) , 851-70, (2002) This publication is the seventh in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers' Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS ... |
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Performance of methyl eugenol + matrix + toxicant combinations under field conditions in Hawaii and California for trapping Bactrocera dorsalis (Diptera: Tephritidae).
J. Econ. Entomol. 106(2) , 727-34, (2013) The oriental fruit fly, Bactrocera dorsalis (Hendel) is a major pest of many fruit crops worldwide. Current detection programs by federal and state agencies in the United States use a grid of traps consisting of liquid methyl eugenol (lure) and naled (toxican... |
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Pharmacological recruitment of aldehyde dehydrogenase 3A1 (ALDH3A1) to assist ALDH2 in acetaldehyde and ethanol metabolism in vivo.
Proc. Natl. Acad. Sci. U. S. A. 112(10) , 3074-9, (2015) Correcting a genetic mutation that leads to a loss of function has been a challenge. One such mutation is in aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2. This mutation is present in ∼ 0.6 billion East Asians and results in accumulation of toxic acetalde... |
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Design and synthesis of 4-methoxyphenylacetic acid esters as 15-lipoxygenase inhibitors and SAR comparative studies of them.
Bioorg. Med. Chem. 17 , 2327-35, (2009) A group of 4-methoxyphenylacetic acid esters were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compounds 7d-e showed the best IC(50) in SLO inhibition (IC(50)=3.... |
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Design, synthesis and SAR studies of 4-allyoxyaniline amides as potent 15-lipoxygensae inhibitors.
Bioorg. Med. Chem. 17 , 1614-22, (2009) A group of 4-allyloxyaniline amides 5a-o were designed, synthesized and evaluated as potential inhibitors of soybean 15-lipoxygenase (SLO) on the basis of eugenol and esteragol structures. Compound 5e showed the best IC(50) in SLO inhibition (IC(50)=0.67+/-0.... |
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Methyleugenol hepatocellular cancer initiating effects in rat liver.
Food Chem. Toxicol. 53 , 187-96, (2013) Methyleugenol (MEG), a constituent of plants used in the human diet, is hepatocarcinogenic in rodents. In an experiment to elucidate its mode of action in rat liver, male F344 rats were administered MEG intragastrically at 3 doses per week for up to 16 weeks ... |