去甲氧基姜黄素
去甲氧基姜黄素结构式
|
常用名 | 去甲氧基姜黄素 | 英文名 | demethoxycurcumin |
|---|---|---|---|---|
| CAS号 | 22608-11-3 | 分子量 | 338.354 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 571.4±50.0 °C at 760 mmHg | |
| 分子式 | C20H18O5 | 熔点 | 168ºC | |
| MSDS | 中文版 美版 | 闪点 | 205.5±23.6 °C | |
| 符号 |
GHS09 |
信号词 | Warning |
|
Therapeutic potential of turmeric in Alzheimer's disease: curcumin or curcuminoids?
Phytother Res. 28(4) , 517-25, (2014) Alzheimer's disease (AD) is the most common form of dementia. There is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. Hence, newer and alternate treatment options are being ... |
|
|
Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation.
Br. J. Nutr. 112(1) , 8-14, (2014) We have previously shown that curcumin (CUR) may increase lipid accumulation in cultured human acute monocytic leukaemia cell line THP-1 monocytes/macrophages, but that tetrahydrocurcumin (THC), an in vivo metabolite of CUR, has no such effect. In the present... |
|
|
Demethoxycurcumin-induced DNA Damage Decreases DNA Repair-associated Protein Expression Levels in NCI-H460 Human Lung Cancer Cells.
Anticancer Res. 35 , 2691-8, (2015) Demethoxycurcumin (DMC) is a key component of Chinese medicine (Turmeric) and has been proven effective in killing various cancer cells. Its role in inducing cytotoxic effects in many cancer cells has been reported, but its role regarding DNA damage on lung c... |
|
|
Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells.
J. Nat. Med. 66(2) , 400-5, (2012) The chemically modified analogs, the demethylated analogs 4-6, the tetrahydro analogs 7-9 and the hexahydro analogs 10-12, of curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3) were evaluated for their inhibitory activity on lipopolysaccharide a... |
|
|
Anti-Acanthamoebic properties of resveratrol and demethoxycurcumin.
Exp. Parasitol. 132(4) , 519-23, (2012) Acanthamoeba is an opportunist protist pathogen that is known to infect the cornea to produce eye keratitis and the central nervous system to produce fatal granulomatous encephalitis. Early diagnosis, followed by aggressive treatment using a combination of dr... |
|
|
Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.
Int. J. Mol. Med. 27(2) , 205-11, (2011) Curcuminoids are the major active components extracted from Curcuma longa and are well known for their antioxidant effects. Previous studies have reported that the antioxidant properties of curcuminoids are mainly attributed to their free radical scavenging a... |
|
|
Anti-inflammatory mechanisms of compounds from Curcuma mangga rhizomes using RAW264.7 macrophage cells.
Nat. Prod. Commun. 5(10) , 1547-50, (2010) Curcuma mangga extract and its compounds were investigated for their anti-inflammatory mechanisms against nitric oxide (NO) and prostaglandin E2 (PGE2) release using RAW 264.7 cells. From bioassay-guided fractionation, demethoxycurcumin (1) was isolated from ... |
|
|
The cellular uptake and cytotoxic effect of curcuminoids on breast cancer cells.
Taiwan. J. Obstet. Gynecol. 51(3) , 368-74, (2012) Curcuminoids (including curcumin) are natural antioxidants demonstrating potent chemopreventive properties against several forms of cancer. This study investigated the antiproliferative and induced apoptotic effects of curcuminoids on three cell lines isolate... |
|
|
A reduced curcuminoid analog as a novel inducer of fetal hemoglobin.
Ann. Hematol. 92(3) , 379-86, (2013) Thalassemia is an inherited disorder of hemoglobin molecules that is characterized by an imbalance of α- and β-globin chain synthesis. Accumulation of unbound α-globin chains in erythroid cells is the major cause of pathology in β-thalassemia. Stimulation of ... |
|
|
Demethoxycurcumin inhibits cell proliferation, migration and invasion in prostate cancer cells.
Oncol. Rep. 28(1) , 85-90, (2012) Curcumin (CUR) is a natural agent that has been demonstrated to effectively inhibit prostate cancer growth. However, natural CUR is relatively unstable and can be easily degraded in vivo. Therefore, it is essential to develop other stable curcuminoids. Demeth... |