22608-11-3

• 常用中文名：去甲氧基姜黄素
• 常用英文名：demethoxycurcumin
• CAS号：22608-11-3
• 分子式：C₂₀H₁₈O₅
• 分子量：338.354
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-02-17 08:00:00
• 更新时间：2026-07-23 22:12:37
• 脱甲氧姜黄素(Demethoxycurcumin)是姜黄素的一种主要活性成分,已被证明有抗炎症和对癌细胞毒性作用。

名称

• 中文名: 脱甲氧姜黄
• 英文名: demethoxycurcumin
• 中文别名: 去甲氧基姜黄色素; 去甲氧基姜黄素,10 MM DMSO 溶液; 去甲氧基姜黄素 Solbio/索莱宝 ID0800; 脱甲氧姜黄标准品; (1E,6E)-1-(4-羟基-3-甲氧基苯基)-7-(4-羟基苯基)庚-1,6-二烯-3,5-二酮; CURCUMIN II|||去甲氧基姜黄素|||DESMETHOXYCURCUMIN|||脱甲氧姜黄|||MONODEMETHOXYCURCUMIN; 去甲氧基姜黄素(脱甲氧姜黄,姜黄素I); 去甲氧基姜黄素(姜黄素I/单去甲氧基姜黄素/脱甲氧姜黄); 脱甲氧姜黄对照品; 脱甲氧姜黄, 来源于姜黄; 单去甲氧基姜黄素(去甲氧基姜黄素); 脱甲氧姜黄DEMETHOXYCURCUMIN; 氘4-去甲氧基姜黄素
• 英文别名: (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; (2E)-DeMethoxy CurcuMin; Feruloyl-P-hydroxycinnnamoylmethane; MonodeMethoxycurcuMin; Curcumin II|||Desmethoxycurcumin|||Monodemethoxycurcumin; DeMethoxyCurcuMin(DesMethoxycurcuMin); 1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-htadiene-3,5-dione; (1E,6E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Demethoxycurcumin (AS); emethoxycurcumin; Demethoxycurcumin; Demethoxycurcumin, 10 mM in DMSO; p-HydroxycinnaMoylferuloylMethane; Demethoxy Curcumin; (E,E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-htadiene-3,5-dione; 1,6-Htadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-, (1E,6E); Curcumin Desmethoxy; D4-Demethoxy Curcumin; (E,E)-demethoxycurcumin; Demethoxycurcumin-RM; DEMETHOXYCURCUMIN(SH); (1E,6E)-Demethoxycurcumin; Z/E-Desmethoxycurcumin; Demethoxycurcumin from Curcuma longa L; (1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-Methoxyphenyl)-1,6-htadiene-3,5-d; 1,6-Htadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl); Demethoxycurcumin (Mixture of Isomers); DEMETHOXYCURCUMIN //BP; 1-(4-Hydroxy-3-Methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-htadiene-3,5-dione

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 571.4±50.0 °C at 760 mmHg
• 熔点: 168ºC
• 分子式: C₂₀H₁₈O₅
• 分子量: 338.354
• 闪点: 205.5±23.6 °C
• 精确质量: 338.115417
• PSA: 83.83000
• LogP: 3.15
• 外观性状: orange
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.660
• 储存条件: 2-8°C
• 水溶解性: DMSO: ≥10mg/mL

生物活性

• 描述: 脱甲氧姜黄素(Demethoxycurcumin)是姜黄素的一种主要活性成分,已被证明有抗炎症和对癌细胞毒性作用。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  信号通路 >> 自噬 >> 自噬
  天然产物 >> 酚类
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Somchit M, et al. Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 2014;15(4):1807-10.

  [2]. Wang X, et al. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models. BMC Complement Altern Med. 2014 Mar 5;14:88.

  [3]. Ko YC, et al. Demethoxycurcumin Alters Gene Expression Associated with DNA Damage, Cell Cycle and Apoptosis in Human Lung Cancer NCI-H460 Cells In Vitro. In Vivo. 2015 01-02;29(1):83-94.

  [4]. Katsidoni V, et al. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit morphine's rewarding effect in rats. Psychopharmacology (Berl). 2014 Dec;231(23):4467-78.

安全

• 符号: GHS09
• 信号词: Warning
• 危害声明: H400
• 警示性声明: P273
• 危害码 (欧洲): N
• 风险声明 (欧洲): 50
• 安全声明 (欧洲): 61
• 危险品运输编码: UN 3077 9 / PGIII
• 海关编码: 29145090

合成路线

932744-42-8 932744-41-7 ~% 22608-12-4 22608-11-3

文献：US2010/48957 A1, ; Page/Page column 4-5 ;

123-08-0 121-33-5 123-54-6 ~52% 22608-11-3

文献：Venkateswarlu, Somepalli; Ramachandra, Marellapudi S.; Subbaraju, Gottumukkala V. Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 23 p. 6374 - 6380

123-08-0 123-54-6 ~% 458-37-7 22608-12-4 详细

文献：Journal of Natural Products, , vol. 61, # 12 p. 1531 - 1534

121-33-5 123-54-6 ~% 458-37-7 22608-12-4 详细

文献：Journal of Natural Products, , vol. 61, # 12 p. 1531 - 1534

123-08-0 121-33-5 123-54-6 ~% 458-37-7 详细

文献：Journal of Natural Products, , vol. 61, # 12 p. 1531 - 1534

121-33-5 ~% 22608-11-3

文献：Molecules, , vol. 16, # 2 p. 1888 - 1900

123-54-6 ~% 22608-11-3

文献：Molecules, , vol. 16, # 2 p. 1888 - 1900

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