齐留通
齐留通结构式
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常用名 | 齐留通 | 英文名 | Zileuton |
|---|---|---|---|---|
| CAS号 | 111406-87-2 | 分子量 | 236.290 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 449.4±47.0 °C at 760 mmHg | |
| 分子式 | C11H12N2O2S | 熔点 | 157-158°C | |
| MSDS | 中文版 美版 | 闪点 | 225.6±29.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Antipruritic mechanisms of topical E6005, a phosphodiesterase 4 inhibitor: inhibition of responses to proteinase-activated receptor 2 stimulation mediated by increase in intracellular cyclic AMP.
J. Dermatol. Sci. 76(3) , 206-13, (2014) Phosphodiesterase 4 (PDE4), which catalyses the conversion of cyclic adenosine 3',5'-monophosphate (cAMP) to 5'-AMP, plays a critical role in the pathogenesis of inflammatory disorders. Pruritus is the main symptom of dermatitides, such as atopic dermatitis, ... |
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Anti-proliferative and pro-apoptotic effects of lichen-derived compound protolichesterinic acid are not mediated by its lipoxygenase-inhibitory activity.
Prostaglandins Leukot. Essent. Fatty Acids 98 , 39-47, (2015) Lipoxygenases (LOXs) and their products are involved in several biological functions and have been associated with carcinogenesis. Protolichesterinic acid (PA), a lichen metabolite, inhibits 5- and 12-LOX and has anti-proliferative effects on various cancer c... |
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