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4-(4-马来酰亚胺基苯基)丁酸-N-琥珀酰亚胺酯

4-(4-马来酰亚胺基苯基)丁酸-N-琥珀酰亚胺酯结构式
4-(4-马来酰亚胺基苯基)丁酸-N-琥珀酰亚胺酯结构式
品牌特惠专场
常用名 4-(4-马来酰亚胺基苯基)丁酸-N-琥珀酰亚胺酯 英文名 succinimidyl 4-(p-maleimidophenyl)butyrate
CAS号 79886-55-8 分子量 356.329
密度 1.5±0.1 g/cm3 沸点 551.1±60.0 °C at 760 mmHg
分子式 C18H16N2O6 熔点 130-131ºC
MSDS 中文版 美版 闪点 287.1±32.9 °C
符号 GHS07
GHS07
信号词 Warning

Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis.

Nat. Commun. 5 , 4478, (2014)

Endometriosis is a common gynaecological disease associated with pelvic pain and infertility. Current treatments include oral contraceptives combined with nonsteroidal anti-inflammatory drugs or surgery to remove lesions, all of which provide a temporary but ...

AFM imaging of immobilized fibronectin: does the surface conjugation scheme affect the protein orientation/conformation?

Langmuir 23(19) , 9745-51, (2007)

Covalent grafting of biomolecules could potentially improve the biocompatibility of materials. However, these molecules have to be grafted in an active conformation to play their biological roles. The present work aims at verifying if the surface conjugation ...

Herceptin-conjugated temperature-sensitive immunoliposomes encapsulating gemcitabine for breast cancer.

Arch. Pharm. Res. 39 , 350-8, (2016)

Gemcitabine (2',2'-difluorodeoxycytidine, GCT) is an analog of deoxycytidine with cytotoxicity for breast cancer cells. However, because of its hepatotoxicity and other side effects, an efficient drug delivery system is needed for better therapeutic outcomes....

Size-Dependent Cellular Uptake of Trans-Activator of Transcription Functionalized Nanoparticles.

J. Biomed. Nanotechnol. 12 , 536-45, (2016)

We investigated the cellular uptake efficiencies of differently-sized silica nanoparticles in the presence and the absence of trans-activator of transcription (TAT) peptide. Silica nanoparticles incorporating fluorescent dye molecules with diameters of 30 to ...

Optimisation of small-scale coupling of A5B7 monoclonal antibody to carboxypeptidase G2.

J. Immunol. Methods 158(1) , 49-56, (1993)

Conjugates of F(ab')2 fragment of the monoclonal antibody A5B7 coupled to carboxypeptidase G2 (CPG2) have been produced using the heterobifunctional reagents 2-mercapto-[S-acetyl]acetic acid, N-hydroxysuccinimide ester (SATA) and m-maleimidobenzoyl-N-hydroxys...

Enzyme coupled immunoassay of insulin using a novel coupling reagent.

J. Biochem. 79 , 233, (1976)

A novel coupling reagent, meta-maleimidobenzoyl N-hydroxysuccinimide ester was synthesized. Using this reagent, insulin was conjugated very easily with beta-D-galactosidase [EC 3.2.1.23] in neutral, aqueous solution. No reduction of the enzyme activity was ob...

Evidence for in situ and in vitro association between beta-dystroglycan and the subsynaptic 43K rapsyn protein. Consequence for acetylcholine receptor clustering at the synapse.

J. Biol. Chem. 273(18) , 11321-6, (1998)

The accumulation of dystrophin and associated proteins at the postsynaptic membrane of the neuromuscular junction and their co-distribution with nicotinic acetylcholine receptor (AChR) clusters in vitro suggested a role for the dystrophin complex in synaptoge...

Preparation of a verifiable peptide-protein immunogen: direction-controlled conjugation of a synthetic fragment of the monitor peptide with myoglobin and application for sequence analysis.

Anal. Biochem. 171(2) , 277-82, (1988)

A useful method for preparing a synthetic peptide-carrying protein for specific antibody production was established. The monitor peptide is a trypsin-sensitive cholecystokinin-releasing peptide purified from rat pancreatic juice on the basis of its stimulator...

Construction of fusogenic vesicles bearing specific antibodies. Targeting of reconstituted Sendai virus envelopes towards neuraminidase-treated human erythrocytes.

J. Biol. Chem. 259(15) , 9813-20, (1984)

The cross-linking reagents succinimidyl-4-(p-maleimidophenyl)-butyrate and N-succinimidyl-3-(2-pyridyldithio)-propionate were used to covalently attach antibodies against human erythrocytes to the thiol-containing paraffin, dodecanethiol. The complex formed, ...

Covalent grafting of fibronectin onto plasma-treated PTFE: influence of the conjugation strategy on fibronectin biological activity.

Macromol. Biosci. 7(5) , 738-45, (2007)

Surface coating of synthetic materials is often considered to improve biomedical devices biocompatibility. In this study, we covalently bound fibronectin (FN) onto ammonia plasma-treated PTFE via two crosslinkers, namely glutaric anhydride (GA) and sulfosucci...