7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine
7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine结构式
|
常用名 | 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine | 英文名 | 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine |
|---|---|---|---|---|
| CAS号 | 84201-40-1 | 分子量 | 224.34600 | |
| 密度 | 1.25g/cm3 | 沸点 | N/A | |
| 分子式 | C10H12N2S2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
|
Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.
Clin. Pharmacol. Ther. 88(3) , 360-8, (2010) Oltipraz is a potential candidate drug for the treatment of liver fibrosis (LF) and liver cirrhosis (LC). The pharmacokinetics of oltipraz and its major rearranged metabolite (7-methyl-6,8-bis(methylthio)H-pyrrolo[1,2-a]pyrazine (RM)) were evaluated after sin... |
|
|
Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz.
Mol. Pharmacol. 48(1) , 15-20, (1995) Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication in vitro (ED50 approximately 10 microM), undergoes extensive metabolism in vivo. Most of the orally administered drug undergoes opening of the dithiolethione ring, reduction, recyclizat... |
期刊文献综述：
更多...