2-羟基吡啶
2-羟基吡啶结构式
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常用名 | 2-羟基吡啶 | 英文名 | 2-pyridone |
|---|---|---|---|---|
| CAS号 | 142-08-5 | 分子量 | 95.099 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 323.7±15.0 °C at 760 mmHg | |
| 分子式 | C5H5NO | 熔点 | 105-107 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 181.1±5.3 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Steroidal Saponins from the Mesocarp of the Fruits of Raphia farinifera (Arecaceae) and their Cytotoxic Activity.
Nat. Prod. Commun. 10 , 1941-4, (2016) Eight steroidal saponins (1-8), including one previously unreported derivative (1), have been isolated from the mesocarp of Raphia farinifera fruits by combined column chromatography and RP-HPLC methods. They were characterized by spectroscopic (1D and 2D NMR... |
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Self-assembled hybrid metal oxide base catalysts prepared by simply mixing with organic modifiers.
Nat. Commun. 6 , 8580, (2015) Multidentate materials formed by simply mixing heterogeneous and homogeneous components are promising for construction of versatile active sites on the surface of heterogeneous compounds, however, to the best of our knowledge, there are no reports on such mat... |
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Janus kinase signaling activation mediates peritoneal inflammation and injury in vitro and in vivo in response to dialysate.
Kidney Int. 86(6) , 1187-96, (2014) Peritoneal membrane pathology limits long-term peritoneal dialysis (PD). Here, we tested whether JAK/STAT signaling is implicated and if its attenuation might be salutary. In cultured mesothelial cells, PD fluid activated, and the pan-JAK inhibitor P6 reduced... |
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Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.
Molecules 19(8) , 11883-95, (2014) Citrus contain various flavonoids and alkaloids that have multiple biological activities. It is known that the immature Citrus contains larger amounts of bioactive components, than do the mature plants. Although Citrus flavonoids are well known for their biol... |
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JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter.
Biochem. Pharmacol. 96 , 52-64, (2015) Inhibition of Janus-activated kinase-1 (JAK1) is a promising clinical concept for post-transplant immunosuppression and autoimmunity. However, it also raises concerns regarding possible immunosuppressive side effects. Our study investigates JAK1 signalling in... |
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Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
J. Med. Chem. 50 , 5780-9, (2007) NAD(P)H:quinone oxidoreductase 1 is a proposed target in pancreatic cancer. We describe the synthesis of a series of indolequinones, based on the 5- and 6-methoxy-1,2-dimethylindole-4,7-dione chromophores with a range of phenolic leaving groups at the (indol-... |
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Excitonic splittings in jet-cooled molecular dimers.
Chimia 65(4) , 228-30, (2011) In more than 60 years of research on molecular excitons, there has been extensive theoretical work but few experimental investigations have rigorously tested the predictions of exciton coupling theories. In centrosymmetric doubly H-bonded molecular dimers wit... |
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FoxM1 Directs STAT3 Expression Essential for Human Endometrial Stromal Decidualization.
Sci. Rep. 5 , 13735, (2015) Human endometrium decidualization, which involves endometrial stromal proliferation and differentiation, is a prerequisite for embryo implantation, thus successful pregnancy. The Forkhead Box M1 (FoxM1), previously known as HNF-3, HFH-11, MPP2, Win, and Tride... |
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Multi-component anion relay cascade of 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile: access to biscyanoethylated furo[3,2-c]pyridinones.
Org. Biomol. Chem. 10(23) , 4571-6, (2012) A highly efficient multi-component anion relay cascade reaction based on 1-acetylcyclopropanecarboxamides, aldehydes and acrylonitrile has been developed, which provides strategically novel and atom-economic access to biologically important biscyanoethylated ... |
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Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy.
PLoS ONE 9(12) , e115068, (2014) Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations. This apoptosis is counteracted by (1) the signaling heteroge... |