2-氯喹啉
2-氯喹啉结构式
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常用名 | 2-氯喹啉 | 英文名 | Chloroquinoline |
|---|---|---|---|---|
| CAS号 | 612-62-4 | 分子量 | 163.604 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 267.3±13.0 °C at 760 mmHg | |
| 分子式 | C9H6ClN | 熔点 | 34-37 °C(lit.) | |
| MSDS | 美版 | 闪点 | 141.2±5.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Antiprotozoal activity of chloroquinoline based chalcones.
Eur. J. Med. Chem. 46 , 1897-905, (2011) A new series of chloroquinoline based chalcones were synthesized and evaluated for in vitro antiamoebic and antimalarial activities. The results showed that out of fifteen compounds, four were found to be more active against the Entamoeba histolytica; while o... |
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Ruthenium-catalyzed cyclization of anilides with substituted propiolates or acrylates: an efficient route to 2-quinolinones.
Org. Lett. 16(13) , 3568-71, (2014) A Ru-catalyzed cyclization of anilides with propiolates or acrylates affording 2-quinolinones having diverse functional groups in good to excellent yields is described. Later, 2-quinolinones were converted into 3-halo-2-quinolinones and 2-chloroquinolines. Th... |
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Chemoenzymatic synthesis of chiral 2,2'-bipyridine ligands and their N-oxide derivatives: applications in the asymmetric aminolysis of epoxides and asymmetric allylation of aldehydes.
Org. Biomol. Chem. 8(5) , 1081-90, (2010) A series of enantiopure 2,2'-bipyridines have been synthesised from the corresponding cis-dihydrodiol metabolites of 2-chloroquinolines. Several of the resulting hydroxylated 2,2'-bipyridines were found to be useful chiral ligands for the asymmetric aminolysi... |
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Discovering some novel 7-chloroquinolines carrying a biologically active benzenesulfonamide moiety as a new class of anticancer agents.
Chem. Pharm. Bull. 61(1) , 50-8, (2013) Based on the reported anticancer activity of quinolines, a new series of 7-chloroquinoline derivatives bearing the biologically active benzenesulfonamide moiety 2-17 and 19-25 were synthesized starting with 4,7-dichloroquinolne 1. Compound 17 was the most act... |
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C-C bond formation at C-2 of a quinoline ring: synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors.
Bioorg. Med. Chem. 20(7) , 2199-207, (2012) A number of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives were synthesized via AlCl(3)-mediated C-C bond forming reaction between 2-chloroquinoline-3-carbonitrile and various indoles. The methodology does not require any N-protection of the indoles em... |
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A physico-chemical and biological study of novel chitosan-chloroquinoline derivative for biomedical applications.
Int. J. Biol. Macromol. 49(3) , 356-61, (2011) This paper describes an elegant cross-linking technique for the preparation of chitosan-chloroquinoline derivative by using a greener technique. Chitosan solution in aqueous acetic acid was treated with 2-chloroquinoline-3-carbaldehyde solution to form hydrog... |
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Transformation of 2-chloroquinoline to 2-chloro-cis-7,8-dihydro-7,8- dihydroxyquinoline by quinoline-grown resting cells of Pseudomonas putida 86.
FEMS Microbiol. Lett. 112(2) , 151-7, (1993) Resting cells of Pseudomonas putida strain 86 were grown on quinoline transformed 2-chloroquinoline to 2-chloro-cis-7,8-dihydro-7,8-dihydroxyquinoline which was not converted further. 7,8-Dioxygenating activity was present when the enzymes of quinoline catabo... |