2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D
2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D结构式
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常用名 | 2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D | 英文名 | 2-((3-TRIFLUOROMETHYL)PHENYL)HISTAMINE D |
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| CAS号 | 162049-83-4 | 分子量 | 487.38300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C20H20F3N3O8 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A | |
| 符号 |
GHS05, GHS06 |
信号词 | Danger |
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Synthesis and histamine H1 receptor agonist activity of a series of 2-phenylhistamines, 2-heteroarylhistamines, and analogues.
J. Med. Chem. 38 , 1287-1294, (1995) New histamine derivatives characterized by a (substituted) aryl, heteroaryl, benzyl, or heteroarylmethyl substituent in the C2 position of the imidazole ring have been prepared from appropriate imidates or amidines, respectively, and 2-oxo-4-phthalimido-1-but... |
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Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion.
Invest. Ophthalmol. Vis. Sci. 53(6) , 2993-3003, (2012) The purpose of this study was to determine the effect of histamine and its receptors on goblet cell secretion.Cultured rat and human goblet cells were grown in RPMI 1640. Goblet cell secretion of high molecular weight glycoconjugate was measured by an enzyme-... |
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Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor.
J. Pharmacol. Exp. Ther. 305 , 1104-1115, (2003) Species isoforms of histamine H2-, H3-, and H4-receptors differ in their pharmacological properties. The study aim was to dissect differences between the human H1R (hH1R) and guinea pig H1R (ghH1R). We coexpressed hH1R and gpH1R with regulators of G-protein s... |
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Histamine directly and synergistically with lipopolysaccharide stimulates cyclooxygenase-2 expression and prostaglandin I(2) and E(2) production in human coronary artery endothelial cells.
J. Immunol. 179(11) , 7899-906, (2007) Although histamine plays an essential role in inflammation, its influence on cyclooxygenases (COX) and prostanoid homeostasis is not well understood. In this study, we investigated the effects of histamine on the expression of COX-1 and COX-2 and determined t... |