5-溴烟酸
5-溴烟酸结构式
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常用名 | 5-溴烟酸 | 英文名 | 5-Bromonicotinic acid |
|---|---|---|---|---|
| CAS号 | 20826-04-4 | 分子量 | 202.01 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | 328.5±27.0 °C at 760 mmHg | |
| 分子式 | C6H4BrNO2 | 熔点 | 178-180 °C(lit.) | |
| MSDS | 美版 | 闪点 | 152.5±23.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Agonist lead identification for the high affinity niacin receptor GPR109a.
Bioorg. Med. Chem. Lett. 17 , 4914-9, (2007) A strategy for lead identification of new agonists of GPR109a, starting from known compounds shown to activate the receptor, is described. Early compound triage led to the formulation of a binding hypothesis and eventually to our focus on a series of pyrazole... |
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Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine.
Bioconjug. Chem. 9(6) , 758-64, (1998) Substituting a pyridine ring for a benzene ring in the acylation agent N-succinimidyl 3-iodobenzoate has resulted in a useful approach for the radiohalogenation of monoclonal antibodies, peptides, and labeled biotin conjugates. It was hypothesized that such a... |
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Drug-protein conjugates: haptenation of 1-methyl-10 alpha-methoxydihydrolysergol and 5-bromonicotinic acid to albumin for the production of epitope-specific monoclonal antibodies against nicergoline.
J. Pharm. Sci. 84(9) , 1120-5, (1995) Two types of monoclonal antibodies were used for the determination of nicergoline in biological matrices. The antibodies were prepared with the hydrolysis products 5-bromonicotinic acid and 1-methyl-10 alpha-methoxydihydrolysergol after hemisuccinoylation to ... |
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Functional diversity among 5-substituted nicotine analogs; in vitro and in vivo investigations.
Eur. J. Pharmacol. 435(2-3) , 171-80, (2002) Two 5-substituted derivatives of nicotine (nicotinic acetylcholine receptor: K(i)=2.4 nM) were synthesized and evaluated: 5-bromonicotine (K(i)=6.9 nM) and 5-methoxynicotine (K(i)=14.3 nM). Despite their high affinity, neither 5-bromonicotine nor 5-methoxynic... |