ML-7盐酸盐
ML-7盐酸盐结构式
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常用名 | ML-7盐酸盐 | 英文名 | ML-7 hydrochloride |
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| CAS号 | 110448-33-4 | 分子量 | 452.738 | |
| 密度 | N/A | 沸点 | 542.7ºC at 760 mmHg | |
| 分子式 | C15H18ClIN2O2S | 熔点 | 246-249ºC dec. | |
| MSDS | 美版 | 闪点 | 282ºC |
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Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature.
Nat. Cell Biol. 17(2) , 137-47, (2015) In many cases, cell function is intimately linked to cell shape control. We used endothelial cell branching morphogenesis as a model to understand the role of myosin II in shape control of invasive cells migrating in 3D collagen gels. We applied principles of... |
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Directional bleb formation in spherical cells under temperature gradient.
Biophys. J. 109 , 355-64, (2015) Living cells sense absolute temperature and temporal changes in temperature using biological thermosensors such as ion channels. Here, we reveal, to our knowledge, a novel mechanism of sensing spatial temperature gradients within single cells. Spherical mitot... |
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MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in Mammalian Eggs Affect Myosin-II Function and Regulate the Metaphase II State in a Calcium- and Zinc-Dependent Manner.
Biol. Reprod. 92 , 146, (2015) Vertebrate eggs are arrested at metaphase of meiosis II, a state classically known as cytostatic factor arrest. Maintenance of this arrest until the time of fertilization and then fertilization-induced exit from metaphase II are crucial for reproductive succe... |
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Pseudomonas fluorescens alters the intestinal barrier function by modulating IL-1β expression through hematopoietic NOD2 signaling.
Inflamm. Bowel Dis. 21(3) , 543-55, (2015) Ileal Crohn's disease is related to NOD2 mutations and to a gut barrier dysfunction. Pseudomonas fluorescens has also been associated with ileal Crohn's disease. The aim of this study was to determine the impact of P. fluorescens on the paracellular permeabil... |
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ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
Toxicol. Mech. Methods 26 , Nov-21, (2016) The study aims at evaluating the combination of the quinocetone and the ML-7 in preclinical hepatocellular carcinoma models. To this end, the effect of quinocetone and ML-7 on apoptosis induction and signaling pathways was analyzed on HepG2 cell lines. Here, ... |
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The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules.
J. Leukoc. Biol. 98 , 223-34, (2015) Sphingolipid- and cholesterol-rich lipid raft microdomains are important in the initiation of BCR signaling. Although it is known that lipid rafts promote the coclustering of BCR and Lyn kinase microclusters within the B cell IS, the molecular mechanism of th... |
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Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin.
Mol. Cancer Res. 13(2) , 273-80, (2015) Chloride intracellular channel 1 (CLIC1) has been shown to be upregulated in various malignancies but its exact function remains unclear. Here, it is revealed that CLIC1 is critical for the stability of invadopodia in endothelial and tumor cells embedded in a... |
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Induction of differentiation of human leukemia cells by inhibitors of myosin light chain kinase.
FEBS Lett. 287 , 175, (1991) Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, ... |
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Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells.
Biochem. Biophys. Res. Commun. 459(4) , 686-91, (2015) Zipper-interacting protein kinase (ZIPK) is known to regulate several functions such as apoptosis, smooth muscle contraction, and cell migration. While exogenously expressed GFP-ZIPK localizes to the cleavage furrow, role of ZIPK in cytokinesis is obscure. He... |