羟基丙酮酸
羟基丙酮酸结构式
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常用名 | 羟基丙酮酸 | 英文名 | Hydroxypyruvic acid |
|---|---|---|---|---|
| CAS号 | 1113-60-6 | 分子量 | 104.06100 | |
| 密度 | 1.546g/cm3 | 沸点 | 252.9ºC at 760mmHg | |
| 分子式 | C3H4O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 121ºC | |
| 符号 |
GHS05, GHS07 |
信号词 | Danger |
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Highly sensitive GC/MS/MS method for quantitation of amino and nonamino organic acids.
Anal. Chem. 83(7) , 2705-11, (2011) Metabolite profiling methods are important tools for measurement of metabolite pools in biological systems. While most metabolite profiling methods report relative intensities or depend on a few internal standards representing all metabolites, the ultimate re... |
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On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A.
J. Am. Chem. Soc. 128(44) , 14325-36, (2006) Feeding experiments with isotope-labeled precursors rule out hydroxypyruvate and TCA cycle intermediates as the metabolic source of methoxymalonyl-ACP, the substrate for incorporation of "glycolate" units into ansamitocin P-3, soraphen A, and other antibiotic... |
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Oocyte and zygote ketoaldehyde utilisation.
Biochim. Biophys. Acta 1355(2) , 99-101, (1997) Mouse oocytes and zygotes, when solubilised demonstrated that a range of ketoaldehydes could be utilised as substrates. Of the five ketoaldehydes investigated the overall substrate utilisation was hydroxypyruvate > glyoxylate > 2-ketobutyrate > pyruvate > gly... |
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Production of hydroxypyruvate from glycerate by a novel biotechnological route.
Bioresour. Technol. 131 , 552-4, (2013) In this work, bio-oxidation of glycerate was introduced for the green production of hydroxypyruvate. Whole cells of Pseudomonas sp. XP-LM were confirmed to have a good ability to produce hydroxypyruvate from glycerate. Under the optimal conditions, Hydroxypyr... |
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Glycerate 2-kinase of Thermotoga maritima and genomic reconstruction of related metabolic pathways.
J. Bacteriol. 190(5) , 1773-82, (2008) Members of a novel glycerate-2-kinase (GK-II) family were tentatively identified in a broad range of species, including eukaryotes and archaea and many bacteria that lack a canonical enzyme of the GarK (GK-I) family. The recently reported three-dimensional st... |
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Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase.
Biochemistry 47(32) , 8271-82, (2008) The crystal structure of Mycobacterium tuberculosis d-3-phosphoglycerate dehydrogenase has been solved with bound effector, l-serine, and substrate, hydroxypyruvic acid phosphate, at resolutions of 2.7 and 2.4 A, respectively. The subunits display the same ex... |
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Molecular and structural characterization of NADPH-dependent d-glycerate dehydrogenase from the enteric parasitic protist Entamoeba histolytica.
Biochem. J. 375(Pt 3) , 729-36, (2003) Putative NADPH-dependent GDH (L-glycerate dehydrogenase) of the protozoan parasite Entamoeba histolytica (EhGDH) has been characterized. The EhGDH gene encodes a protein of 318 amino acids with a calculated isoelectric point of 6.29 and a molecular mass of 35... |
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Molecular cloning and characterization of Plasmodium falciparum transketolase.
Mol. Biochem. Parasitol. 160(1) , 32-41, (2008) The pentose phosphate pathway (PPP) is an important metabolic pathway for yielding reducing power in the form of NADPH and production of pentose sugar needed for nucleic acid synthesis. Transketolase, the key enzyme of non-oxidative arm of PPP, plays a vital ... |
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Potential cytotoxic effect of hydroxypyruvate produced from D-serine by astroglial D-amino acid oxidase.
J. Biochem. 148(6) , 743-53, (2010) D-amino acid oxidase (DAO) is a flavoenzyme that exists in the kidney, liver and brain of mammals. This enzyme catalyzes the oxidation of D-amino acids to the corresponding α-keto acid, hydrogen peroxide and ammonia. Recently D-serine, one of the substrates o... |
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High resolution 1H NMR investigations of the reactivities of alpha-keto acid anions with hydrogen peroxide.
Free Radic. Res. 26(2) , 145-57, (1997) The chemical reactivity of various alpha-keto acid anions (beta-hydroxypyruvate, beta-phenylpyruvate, 2-ketobutyrate and 2-ketoglutarate) with hydrogen peroxide (H2O2) was investigated at physiological pH (7.4) and a temperature of 25 degrees C. The initial c... |