烟曲霉素C, 来源于烟曲霉菌
烟曲霉素C, 来源于烟曲霉菌结构式
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常用名 | 烟曲霉素C, 来源于烟曲霉菌 | 英文名 | Fumitremorgin C |
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| CAS号 | 118974-02-0 | 分子量 | 379.452 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 642.9±55.0 °C at 760 mmHg | |
| 分子式 | C22H25N3O3 | 熔点 | 259.5-260.5℃ | |
| MSDS | 中文版 美版 | 闪点 | 342.6±31.5 °C |
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The impact of CLAUDIN-1 on follicular thyroid carcinoma aggressiveness.
Endocr. Relat. Cancer 22 , 819-30, (2015) CLAUDIN-1 belongs to the family of transmembrane tight junction proteins tightening the paracellular cleft of epithelial cells. In human malignancies, CLAUDIN-1 is often dysregulated and located in subcellular compartments, particularly in the nucleus where i... |
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Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 213-8, (2014) A simple and rapid ultra-high performance liquid chromatography-mass spectrometry/mass spectrometry (UPLC-MS/MS) method has been developed for measuring intracellular concentrations of the anticancer agent 7-ethyl-10-hydroxycamptothecin (SN-38) in tumour cell... |
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Quantitative mass spectrometry imaging of emtricitabine in cervical tissue model using infrared matrix-assisted laser desorption electrospray ionization.
Anal. Bioanal. Chem 407(8) , 2073-84, (2015) A quantitative mass spectrometry imaging (QMSI) technique using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) is demonstrated for the antiretroviral (ARV) drug emtricitabine in incubated human cervical tissue. Method developme... |
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Hypoxia Induces a Metabolic Shift and Enhances the Stemness and Expansion of Cochlear Spiral Ganglion Stem/Progenitor Cells.
Biomed Res. Int. 2015 , 359537, (2015) Previously, we demonstrated that hypoxia (1% O2) enhances stemness markers and expands the cell numbers of cochlear stem/progenitor cells (SPCs). In this study, we further investigated the long-term effect of hypoxia on stemness and the bioenergetic status of... |
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A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours.
BMC Cancer 15 , 199, (2015) Mounting evidence demonstrates a causal role for S100 proteins in tumourigenesis and several S100 isoforms have shown utility as biomarkers of several types of cancer. The S100 family is comprised of 21 small isoforms, many of them implicated in important cel... |
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In vitro and in vivo identification of ABCB1 as an efflux transporter of bosutinib.
J. Hematol. Oncol. 8 , 81, (2015) Bosutinib is a recently approved ABL inhibitor. In spite of the well-documented effectiveness of BCR-ABL inhibitors in treating chronic myeloid leukemia, development of resistance is a continuous clinical challenge. Transporters that facilitate drug uptake an... |
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5-Aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines.
Biosci. Biotechnol. Biochem. 79(3) , 422-31, (2015) 5-aminolevulinic acid (5-ALA) is contained in all organisms and a starting substrate for heme biosynthesis. Since administration of 5-ALA specifically leads cancer cells to accumulate protoporphyrin IX (PpIX), a potent photosensitizer, we tested if 5-ALA also... |
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Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis.
Infect. Immun. 83 , 2614-26, (2015) Candida albicans, a commensal fungus of the oral microbiome, causes oral candidiasis in humans with localized or systemic immune deficiencies. Secreted aspartic proteinases (Saps) are a family of 10 related proteases and are virulence factors due to their pro... |
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The effects of HAART on the expression of MUC1 and P65 in a cervical cancer cell line, HCS-2.
Biomed. Pharmacother. 71 , 227-32, (2015) Cervical cancer is the third most commonly diagnosed cancer globally and it is one of three AIDS defining malignancies. Highly active antiretroviral therapy (HAART) is a combination of three or more antiretroviral drugs and has been shown to play a significan... |
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Testosterone regulates thyroid cancer progression by modifying tumor suppressor genes and tumor immunity.
Carcinogenesis 36 , 420-8, (2015) Cancer gender disparity has been observed for a variety of human malignancies. Thyroid cancer is one such cancer with a higher incidence in women, but more aggressive disease in men. There is scant evidence on the role of sex hormones on cancer initiation/pro... |