硫甲磺酸钠
硫甲磺酸钠结构式
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常用名 | 硫甲磺酸钠 | 英文名 | Sodium Methanethiosulfonate |
|---|---|---|---|---|
| CAS号 | 1950-85-2 | 分子量 | 134.15300 | |
| 密度 | N/A | 沸点 | 233.3ºC at 760 mmHg | |
| 分子式 | CH3NaO2S2 | 熔点 | 272-273.5ºC | |
| MSDS | 美版 | 闪点 | 94.9ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Large scale production of the active human ASCT2 (SLC1A5) transporter in Pichia pastoris--functional and kinetic asymmetry revealed in proteoliposomes.
Biochim. Biophys. Acta 1828(9) , 2238-46, (2013) The human glutamine/neutral amino acid transporter ASCT2 (hASCT2) was over-expressed in Pichia pastoris and purified by Ni(2+)-chelating and gel filtration chromatography. The purified protein was reconstituted in liposomes by detergent removal with a batch-w... |
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About half of the late sodium current in cardiac myocytes from dog ventricle is due to non-cardiac-type Na(+) channels.
J. Mol. Cell. Cardiol. 53(5) , 593-8, (2012) Voltage gated sodium channels (Na(V)s) are essential to propagate neuronal and cardiac electrical impulses. While the cardiac Na(+) current (I(Na)) is often all attributed to the cardiac isoform, Na(V)1.5, some evidence suggests that other Na(+) channel isofo... |
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Interaction sites of tropomyosin in muscle thin filament as identified by site-directed spin-labeling.
Biophys. J. 100(10) , 2432-9, (2011) To identify interaction sites we measured the rotational motion of a spin label covalently bound to the side chain of a cysteine genetically incorporated into rabbit skeletal muscle tropomyosin (Tm) at positions 13, 36, 146, 160, 174, 190, 209, 230, 271, and ... |
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Insights into the mechanism of pore opening of acid-sensing ion channel 1a.
J. Biol. Chem. 286(18) , 16297-307, (2011) Acid-sensing ion channels (ASICs) are trimeric cation channels that undergo activation and desensitization in response to extracellular acidification. The underlying mechanism coupling proton binding in the extracellular region to pore gating is unknown. Here... |
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GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites.
J. Neurochem. 128(3) , 363-75, (2014) Alcohols and inhaled anesthetics modulate GABA(A) receptor (GABA(A)R) function via putative binding sites within the transmembrane regions. The relative position of the amino acids lining these sites could be either inter- or intra-subunit. We introduced cyst... |
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Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis.
Am. J. Physiol. Cell Physiol. 300(5) , C1034-46, (2011) We report the novel, heterozygous AE1 mutation R730C associated with dominant, overhydrated, cation leak stomatocytosis and well-compensated anemia. Parallel elevations of red blood cell cation leak and ouabain-sensitive Na(+) efflux (pump activity) were appa... |
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Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.
Biochemistry 51(19) , 3971-81, (2012) Opening and closing of the cystic fibrosis transmembrane conductance regulator chloride channel are controlled by interactions of ATP with its cytoplasmic nucleotide binding domains (NBDs). The NBDs are connected to the transmembrane pore via four cytoplasmic... |
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Screening systems for the identification of S-nitrosylated proteins.
Nitric Oxide 25(2) , 108-11, (2011) S-nitrosylation is a well-characterized reaction involving the covalent binding of nitric oxide (NO) to cysteine residues (Cys) in a protein. Similar to protein phosphorylation, S-nitrosylation is a post-translational modification involved in the regulation o... |
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Identification of cysteines involved in the effects of methanethiosulfonate reagents on human equilibrative nucleoside transporter 1.
Mol. Pharmacol. 80(4) , 735-46, (2011) Inhibitor and substrate interactions with equilibrative nucleoside transporter 1 (ENT1; SLC29A1) are known to be affected by cysteine-modifying reagents. Given that selective ENT1 inhibitors, such as nitrobenzylmercaptopurine riboside (NBMPR), bind to the N-t... |
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Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.
Anal. Biochem. 393(2) , 215-21, (2009) Prolyl hydroxylase domain 2 (PHD2) plays an important role in hypoxic sensing in humans. Here we report studies on the reactivity of cysteinyl residues of the catalytic domain of PHD2 using an approach in which nondenaturing electrospray ionization-mass spect... |