Purvalanol A.
Purvalanol A.结构式
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常用名 | Purvalanol A. | 英文名 | Purvalanol A |
|---|---|---|---|---|
| CAS号 | 212844-53-6 | 分子量 | 388.894 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 590.5±60.0 °C at 760 mmHg | |
| 分子式 | C19H25ClN6O | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 310.9±32.9 °C |
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Phosphoproteomic Analysis of Aurora Kinase Inhibition in Monopolar Cytokinesis.
J. Proteome Res. 14 , 4087-98, (2015) Cytokinesis is the last step of the cell cycle that requires coordinated activities of the microtubule cytoskeleton, actin cytoskeleton, and membrane compartments. Aurora B kinase is one of the master regulatory kinases that orchestrate multiple events during... |
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Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Cell Cycle 14 , 1842-58, (2015) Polyploid decidual cells are specifically differentiated cells during mouse uterine decidualization. However, little is known about the regulatory mechanism and physiological significance of polyploidization in pregnancy. Here we report a novel role of E2F8 i... |
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KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
Oncogene 34(11) , 1432-41, (2015) Aberrant splicing of the cyclin-dependent kinase-associated phosphatase, KAP, promotes glioblastoma invasion in a Cdc2-dependent manner. However, the mechanism by which this occurs is unknown. Here we show that miR-26a, which is often amplified in glioblastom... |
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Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).
Xenobiotica 46 , 416-23, (2016) 1. Purine cyclin-dependent kinase inhibitors have recently been recognised as promising candidates for the treatment of various cancers. While pharmacodynamic properties of these compounds are relatively well understood, their pharmacokinetics including possi... |
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Phosphorylation of the centrosomal protein, Cep169, by Cdk1 promotes its dissociation from centrosomes in mitosis.
Biochem. Biophys. Res. Commun. 468 , 642-6, (2015) Cep169 is a centrosomal protein conserved among vertebrates. In our previous reports, we showed that mammalian Cep169 interacts and collaborates with CDK5RAP2 to regulate microtubule (MT) dynamics and stabilization. Although Cep169 is required for MT regulati... |
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Stochastic Measurement Models for Quantifying Lymphocyte Responses Using Flow Cytometry.
PLoS ONE 11 , e0146227, (2016) Adaptive immune responses are complex dynamic processes whereby B and T cells undergo division and differentiation triggered by pathogenic stimuli. Deregulation of the response can lead to severe consequences for the host organism ranging from immune deficien... |