氯-IB-MECA
氯-IB-MECA结构式
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常用名 | 氯-IB-MECA | 英文名 | 2-CL-IB-MECA |
|---|---|---|---|---|
| CAS号 | 163042-96-4 | 分子量 | 544.731 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C18H18ClIN6O4 | 熔点 | 209 °C | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma.
Cancer Chemother. Pharmacol. 74(4) , 847-60, (2014) Metastatic melanoma is considered one of the most aggressive malignant tumours, representing the deadliest form of skin cancer. Melanoma progression is associated with the abrogation of normal controls that limit cell proliferation, migration, and invasion, e... |
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Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus.
J. Neurosci. 17 , 607-614, (1997) The adenosine A3 receptor is expressed in brain, but the consequences of activation of this receptor on electrophysiological activity are unknown. We have characterized the actions of a selective adenosine A3 receptor agonist, 2-chloro-N6-(3-lodobenzyl)-adeno... |
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Modulation of A1 and A2B adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy.
Cell Death Dis. 5 , e1539, (2014) Therapies that target the signal transduction and biological characteristics of cancer stem cells (CSCs) are innovative strategies that are used in combination with conventional chemotherapy and radiotherapy to effectively reduce the recurrence and significan... |
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A novel cardioprotective function of adenosine A1 and A3 receptors during prolonged simulated ischemia.
Am. J. Physiol. 273 , H501-H505, (1997) The possible cardioprotective roles of adenosine A1 and A3 receptors were investigated in a cardiac myocyte model of injury. The adenosine A3 receptor is a novel cardiac receptor capable of mediating potentially important cardioprotective functions. Prolonged... |
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Adenosine A3 receptor agonists protect HL-60 and U-937 cells from apoptosis induced by A3 antagonists.
Biochem. Biophys. Res. Commun. 232 , 317, (1997) The effects of novel, selective adenosine (ADO) A3 receptor antagonists of diverse structure on cells of the human HL-60 leukemia and U-937 lymphoma cell lines were examined. Both 3-ethyl 5-benzyl 2-methyl-6-phenyl-4-phenylethynyl-1,4-(+/-)-dihydropyridine-3,... |