(-)-薄荷醇
(-)-薄荷醇结构式
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常用名 | (-)-薄荷醇 | 英文名 | L-Menthol |
|---|---|---|---|---|
| CAS号 | 2216-51-5 | 分子量 | 156.265 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 215.4±8.0 °C at 760 mmHg | |
| 分子式 | C10H20O | 熔点 | 41-43ºC | |
| MSDS | 中文版 美版 | 闪点 | 93.3±0.0 °C | |
| 符号 |
GHS05, GHS07 |
信号词 | Danger |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.
Antimicrob. Agents Chemother. 53 , 1898-906, (2009) Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have shown that tampon additives can influence staphylococcal TSST-... |
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Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.
PLoS ONE 10 , e0137070, (2015) Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular actions in the brain. Studies were undertaken to examine w... |
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Function and postnatal changes of dural afferent fibers expressing TRPM8 channels.
Mol. Pain 11 , 37, (2015) Genome-wide association studies have identified TRPM8 (transient receptor potential melastatin 8) as one of the susceptibility genes for common migraine. Here, we investigated the postnatal changes of TRPM8-expressing dural afferent fibers as well as the func... |
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Menthol inhibits detrusor contractility independently of TRPM8 activation.
PLoS ONE 9(11) , e111616, (2014) Agonists such as icilin and menthol can activate the cool temperature-sensitive ion channel TRPM8. However, biological responses to menthol may occur independently of TRPM8 activation. In the rodent urinary bladder, menthol facilitates the micturition reflex ... |
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Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers--a powerful strategy for breast cancer diagnosis.
Talanta 89 , 360-8, (2012) A sensitive assay to identify volatile organic metabolites (VOMs) as biomarkers that can accurately diagnose the onset of breast cancer using non-invasively collected clinical specimens is ideal for early detection. Therefore the aim of this study was to esta... |
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Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.
Mol. Pharmacol. 87(1) , 87-95, (2015) In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an extracellular orthosteric site, located at the interface of tw... |
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Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats.
Support Care Cancer 24 , 233-42, (2015) Cold and mechanical allodynia caused by oxaliplatin-induced acute peripheral neuropathy frequently occur after drug infusion. Low-level laser therapy (LLLT) has been used to improve pain symptoms associated with various conditions and may have potential as a ... |
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Expanding the ChemGPS chemical space with natural products.
J. Nat. Prod. 68 , 985-91, (2005) Recently various attempts have been made to increase the efficacy and precision of chemical libraries used in high-throughput screening (HTS) drug discovery approaches. One such approach is ChemGPS, which provides a defined chemical space for prescreening eva... |
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Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
J. Med. Chem. 53 , 5085-107, (2010)
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