二氯苯并咪唑呋喃型核糖苷
二氯苯并咪唑呋喃型核糖苷结构式
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常用名 | 二氯苯并咪唑呋喃型核糖苷 | 英文名 | 5,6-Dichlorobenzimidazole riboside |
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| CAS号 | 53-85-0 | 分子量 | 319.141 | |
| 密度 | 1.8±0.1 g/cm3 | 沸点 | 606.2±65.0 °C at 760 mmHg | |
| 分子式 | C12H12Cl2N2O4 | 熔点 | 222-224ºC | |
| MSDS | 中文版 美版 | 闪点 | 320.4±34.3 °C |
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Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription by RF-amide-related peptide-3 and kisspeptin in a novel GnRH-secreting cell line, mHypoA-GnRH/GFP.
J. Neuroendocrinol. 26(12) , 888-97, (2014) RF-amide-related peptide-3 [RFRP-3; also often referred to as the mammalian orthologue of the avian gonadotrophin-inhibitory hormone (GnIH)] and kisspeptin have emerged as potent modulators of neuroendocrine function via direct regulation of the reproductive ... |
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GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility.
Traffic 16 , 941-61, (2015) Glycogen synthase kinase 3 (GSK-3) has been linked to regulation of kinesin-dependent axonal transport in squid and flies, and to indirect regulation of cytoplasmic dynein. We have now found evidence for direct regulation of dynein by mammalian GSK-3β in both... |
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Upregulation of CYP1B1 expression by inflammatory cytokines is mediated by the p38 MAP kinase signal transduction pathway.
Carcinogenesis 35(11) , 2534-43, (2014) Cytochrome P450 1B1 (CYP1B1) is an enzyme that has a unique tumor-specific pattern of expression and is capable of bioactivating a wide range of carcinogenic compounds. We have reported previously that coordinated upregulation of CYP1B1 by inflammatory cytoki... |
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Glucocorticoids stimulate endolymphatic water reabsorption in inner ear through aquaporin 3 regulation.
Pflugers Arch. 467 , 1931-43, (2015) Menière's disease, clinically characterized by fluctuating, recurrent, and invalidating vertigo, hearing loss, and tinnitus, is linked to an increase in endolymph volume, the so-called endolymphatic hydrops. Since dysregulation of water transport could accoun... |
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Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.
EMBO J. 34 , 1399-416, (2015) Mutations of CSB account for the majority of Cockayne syndrome (CS), a devastating hereditary disorder characterized by physical impairment, neurological degeneration and segmental premature aging. Here we report the generation of a human CSB-knockout cell li... |
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The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine.
Oncol. Rep. 34 , 3304-10, (2015) Pancreatic cancer is a highly aggressive malignancy with a notoriously dismal prognosis. A major contributor to this poor clinical outcome is pancreatic cancer's prominent chemoresistance. The present study was undertaken to determine whether the flavonoid p‑... |
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Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro.
Int. J. Mol. Med. 35 , 1773-8, (2015) Regucalcin plays a pivotal role as a suppressor protein in signal transduction in various types of cells and tissues. The regucalcin gene is localized on the X chromosome. and its expression has been shown to be suppressed in various types of tumor tissue in ... |
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Tracing the molecular basis of transcriptional dynamics in noisy data by using an experiment-based mathematical model.
Nucleic Acids Res. 43(1) , 153-61, (2015) Changes in transcription factor levels, epigenetic status, splicing kinetics and mRNA degradation can each contribute to changes in the mRNA dynamics of a gene. We present a novel method to identify which of these processes is changed in cells in response to ... |
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Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System.
J. Biol. Chem. 290 , 16343-56, (2015) The adult CNS does not spontaneously regenerate after injury, due in large part to myelin-associated inhibitors such as myelin-associated glycoprotein (MAG), Nogo-A, and oligodendrocyte-myelin glycoprotein. All three inhibitors can interact with either the No... |
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Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics.
Nat. Commun. 6 , 6632, (2015) Nonsense-mediated mRNA decay (NMD) limits the production of aberrant mRNAs containing a premature termination codon and also controls the levels of endogenous transcripts. Here we show that when human cells are treated with clinically used chemotherapeutic co... |