羧基酰胺
羧基酰胺结构式
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常用名 | 羧基酰胺 | 英文名 | L-651,582 |
|---|---|---|---|---|
| CAS号 | 99519-84-3 | 分子量 | 424.67 | |
| 密度 | 1.65g/cm3 | 沸点 | 685.5ºC at 760 mmHg | |
| 分子式 | C17H12Cl3N5O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 368.3ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Comparison of the applicability of mass spectrometer ion sources using a polarity- molecular weight scattergram with a 600 sample in-house chemical library.
Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 91-6, (2015) To provide a practical guideline for the selection of a mass spectrometer ion source, we compared the applicability of three types of ion source: direct analysis in real time (DART), electrospray ionization (ESI) and fast atom bombardment (FAB), using an in-h... |
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Differentially expressed and activated proteins associated with non small cell lung cancer tissues.
Respir. Res. 16 , 74, (2015) Lung cancer is a leading cause of mortality. The most common cancer subtype, non small cell lung cancer (NSCLC), accounts for 85-90% all cases and is mainly caused by environmental and genetic factors. Mechanisms involved in lung carcinogenesis include deregu... |
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Intergenerational cultural conflict, mental health, and educational outcomes among Asian and Latino/a Americans: Qualitative and meta-analytic review.
Psychol. Bull. 141(2) , 404-46, (2015) Among immigrant Asian and Latino groups, the contrast between collectivism in traditional heritage and individualism in the mainstream American cultures presents unique challenges for their family relationships. This systematic review was designed to answer 3... |
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Increased B and T Cell Responses in M. bovis Bacille Calmette-Guérin Vaccinated Pigs Co-Immunized with Plasmid DNA Encoding a Prototype Tuberculosis Antigen.
PLoS ONE 10 , e0132288, (2015) The only tuberculosis vaccine currently available, bacille Calmette-Guérin (BCG) is a poor inducer of CD8(+) T cells, which are particularly important for the control of latent tuberculosis and protection against reactivation. As the induction of strong CD8(+... |
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Maintenance therapy in non-small cell lung cancer.
Expert Rev. Anticancer Ther. 15 , 839-46, (2015) Several randomized trials have investigated the role of maintenance treatment for patients with advanced non-small cell lung cancer (NSCLC) not progressed after completion of first-line chemotherapy, with good performance score (PS) and no persistent chemothe... |
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Carboxyamidotriazole inhibits cell growth of imatinib-resistant chronic myeloid leukaemia cells including T315I Bcr-Abl mutant by a redox-mediated mechanism.
Cancer Lett. 300(2) , 205-14, (2011) Mutation of the Bcr-Abl oncoprotein is one of most frequent mechanisms by which chronic myelogenous leukemia (CML) cells become resistant to imatinib. Here, we show that treatment of cell lines harbouring wild type or mutant BCR-ABL with carboxyamidotriazole ... |
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Carboxyamido-triazole inhibits proliferation of human breast cancer cells via G(2)/M cell cycle arrest and apoptosis.
Eur. J. Pharmacol. 538(1-3) , 15-22, (2006) Carboxyamido-triazole (CAI), a voltage-independent calcium channel inhibitor, has been shown to be able to induce growth inhibition and apoptosis in cancer cells. In the present study, we demonstrate that CAI significantly inhibits proliferation of cultured M... |
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A phase I study of paclitaxel and continuous daily CAI in patients with refractory solid tumors.
Cancer Biol. Ther. 8(19) , 1800-5, (2009) Carboxyamido-triazole (CAI) is a calcium influx inhibitor with anti-angiogenic and anti-invasive properties and stabilizes tumor progression in patients. We hypothesized daily oral micronized CAI with q3 week paclitaxel would be well-tolerated and active.Twen... |
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Carboxyamido-triazole modulates retinal pigment epithelial and choroidal endothelial cell attachment, migration, proliferation, and MMP-2 secretion of choroidal endothelial cells.
Curr. Eye Res. 30(2) , 103-13, (2005) To determine the effect of the calcium signaling modulating drug carboxyamido-triazole (CAI) on substeps of exudative age-related macular degeneration (AMD) in vitro.Zymography and ELISA determined the effect of CAI on MMP-2 production of choroidal endothelia... |
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Targeting retinal and choroid neovascularization using the small molecule inhibitor carboxyamidotriazole.
Brain Res. Bull. 81(2-3) , 320-6, (2010) Neovascular ocular diseases as exemplified by proliferative diabetic retinopathy (PDR), exudative age-related macular degeneration (AMD), and retinopathy of prematurity (ROP) are severe diseases affecting all age groups in the US. We asked whether a small mol... |