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氯甲酸氯甲酯

一般危化品
氯甲酸氯甲酯结构式
氯甲酸氯甲酯结构式
常用名 氯甲酸氯甲酯 英文名 Chloromethyl chloroformate
CAS号 22128-62-7 分子量 128.942
密度 1.5±0.1 g/cm3 沸点 107.9±13.0 °C at 760 mmHg
分子式 C2H2Cl2O2 熔点 <-20ºC
MSDS 中文版 美版 闪点 25.5±15.2 °C
符号 GHS05 GHS06
GHS05, GHS06
信号词 Danger

Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes.

Bioorg. Med. Chem. 8(7) , 1719-25, (2000)

A series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes 5 was synthesised by the sequential reaction of 1-aryl-3-methyltriazenes with (i) chloromethyl chloroformate, (ii) NaI in dry acetone, and (iii) either the silver carboxylate or the carboxylic ac...

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media.

Arch. Pharm. (Weinheim) 340(1) , 32-40, (2007)

Aminocarbonyloxymethyl ester prodrugs are known to undergo rearrangement in aqueous solutions to form the corresponding N-acylamine side product via an O-->N intramolecular acyl transfer from the carbamate conjugate base. Novel aminocarbonyloxymethyl esters o...

Water soluble cyclosporine monomethoxy poly(ethyleneglycol) conjugates as potential prodrugs.

Arch. Pharm. Res. 27(6) , 662-9, (2004)

The highly water-soluble monomethoxypoly(ethyleneglycol) (mPEG) prodrugs of cyclosporin A (CsA) were synthesized. These prodrugs were prepared by initially preparing intermediate in the form of carbonate at the 3'-positions of CsA with chloromethyl chloroform...