阿西替尼
阿西替尼结构式
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常用名 | 阿西替尼 | 英文名 | Axitinib |
|---|---|---|---|---|
| CAS号 | 319460-85-0 | 分子量 | 386.470 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 668.9±55.0 °C at 760 mmHg | |
| 分子式 | C22H18N4OS | 熔点 | 213-215ºC | |
| MSDS | 中文版 美版 | 闪点 | 358.3±31.5 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1 (HS3ST3B1) promotes angiogenesis and proliferation by induction of VEGF in acute myeloid leukemia cells.
J. Cell. Biochem. 116(6) , 1101-12, (2015) Heparan sulfate (HS) are complex polysaccharides that reside on the plasma membrane of almost all mammalian cells, and play an important role in physiological and pathological conditions. Heparan sulfate D-glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1) parti... |
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Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease.
Invest. Ophthalmol. Vis. Sci. 56 , 3140-8, (2015) The contribution of lymphangiogenesis (LA) to allergy has received considerable attention and therapeutic inhibition of this process via targeting VEGF has been considered. Likewise, certain inflammatory settings affecting the ocular mucosa can trigger pathog... |
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Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia.
J. Pathol. 235(4) , 632-45, (2015) Chronic inflammation induces lymphangiogenesis and blood vessel remodelling. Since aged pneumonia patients often have repeated episodes of aspiration pneumonia, the pathogenesis may involve chronic inflammation. For lymphangiogenesis, VEGFR-3 and its ligand V... |
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VEGF-C and aortic cardiomyocytes guide coronary artery stem development.
J. Clin. Invest. 124(11) , 4899-914, (2014) Coronary arteries (CAs) stem from the aorta at 2 highly stereotyped locations, deviations from which can cause myocardial ischemia and death. CA stems form during embryogenesis when peritruncal blood vessels encircle the cardiac outflow tract and invade the a... |