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2,6-二氟苯乙酸

2,6-二氟苯乙酸结构式
2,6-二氟苯乙酸结构式
品牌特惠专场
常用名 2,6-二氟苯乙酸 英文名 (2,6-Difluorophenyl)acetic acid
CAS号 85068-28-6 分子量 172.129
密度 1.4±0.1 g/cm3 沸点 251.6±25.0 °C at 760 mmHg
分子式 C8H6F2O2 熔点 100-102 °C(lit.)
MSDS 中文版 美版 闪点 106.0±23.2 °C
符号 GHS07
GHS07
信号词 Warning

Design and synthesis of Rho kinase inhibitors (II).

Bioorg. Med. Chem. 15 , 350-364, (2007)

In a previous study, we identified several structurally unrelated scaffolds of the Rho kinase inhibitor using pharmacophore information obtained from the results of a high-throughput screening and structural information from a homology model of Rho kinase. 1H...

Optimization of benzyloxazoles as non-nucleoside inhibitors of HIV-1 reverse transcriptase to enhance Y181C potency.

Bioorg. Med. Chem. Lett. 23(4) , 1110-3, (2013)

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved activity towards Tyr181Cys containing variants was pursued with the assistance of free energy perturbation (FEP) calculations. Optimization of the 4-R substituent in 1 led to eth...