水飞蓟宁

更新时间：2025-08-20 11:49:02

水飞蓟宁结构式	常用名	水飞蓟宁	英文名	Silidianin
	CAS号	29782-68-1	分子量	482.436
	密度	1.7±0.1 g/cm3	沸点	819.0±65.0 °C at 760 mmHg
	分子式	C₂₅H₂₂O₁₀	熔点	191 °C
	MSDS	中文版美版	闪点	285.0±27.8 °C
	符号	GHS07	信号词	Warning

水飞蓟宁用途

Silydianin 是水飞蓟的活性成分,具有抗胶原酶和抗弹性酶活性。Silydianin 是一种天然的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂,其 IC50 值为 17.38 μM。Silydianin 对氧化产物的体外产生和释放具有抑制作用。

中文名	水飞蓟宁
英文名	silydianin
中文别名	异水飞蓟素
英文别名	更多

描述	Silydianin 是水飞蓟的活性成分,具有抗胶原酶和抗弹性酶活性。Silydianin 是一种天然的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂,其 IC50 值为 17.38 μM。Silydianin 对氧化产物的体外产生和释放具有抑制作用。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶
参考文献	[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6). [2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291. [3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.

描述

相关类别

研究领域 >> 癌症

信号通路 >> 代谢酶/蛋白酶 >> 磷酸酶

参考文献

[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6).

[2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291.

[3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.

密度	1.7±0.1 g/cm3
沸点	819.0±65.0 °C at 760 mmHg
熔点	191 °C
分子式	C₂₅H₂₂O₁₀
分子量	482.436
闪点	285.0±27.8 °C
精确质量	482.121307
PSA	162.98000
LogP	1.84
InChIKey	CYGIJEJDYJOUAN-UHFFFAOYSA-N
SMILES	COc1cc(C2C3C=C(C4Oc5cc(O)cc(O)c5C(=O)C4O)C4C2COC4(O)C3=O)ccc1O
蒸汽压	0.0±3.1 mmHg at 25°C
折射率	1.747
储存条件	2-8°C

符号	GHS07
信号词	Warning
危害声明	H302
警示性声明	P301 + P312 + P330
危害码 (欧洲)	Xn
风险声明 (欧洲)	22
安全声明 (欧洲)	22-45
危险品运输编码	NONH for all modes of transport
WGK德国	3.0

Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.

Pharmacol. Res. 25(2) , 147-54, (1992)

The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver micro...

[Silymarin in the treatment of chronic liver diseases: past and future].

Orv. Hetil. 149(51) , 2413-8, (2008)

In the treatment of chronic liver diseases adequate therapy can be chosen only in the knowledge of pathogenetic processes. In the liver diseases caused by oxidative stress (alcoholic and non-alcoholic...

Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

J. Chromatogr. A. 1116(1-2) , 57-68, (2006)

A selective and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the characterization of silymarin in commercially available milk thistle extract. In t...

实验名称：Inhibition of monophenolase activity of mushroom tyrosinase assessed as increase in l...
来源：ChEMBL
靶标：Polyphenol oxidase 2
External Id：CHEMBL4402624

实验名称：Inhibition of OATP1B1 (unknown origin) expressed in HEK293 cells assessed as reductio...
来源：ChEMBL
靶标：Solute carrier organic anion transporter family member 1B1
External Id：CHEMBL3532587

实验名称：Inhibition of OATP1B3 (unknown origin) expressed in HEK293 cells assessed as reductio...
来源：ChEMBL
靶标：Solute carrier organic anion transporter family member 1B3
External Id：CHEMBL3529885

实验名称：Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in ...
来源：ChEMBL
靶标：Polyphenol oxidase 2
External Id：CHEMBL4402626

实验名称：Binding affinity to mushroom tyrosinase assessed as Stern-Volmer quenching constant b...
来源：ChEMBL
靶标：Polyphenol oxidase 2
External Id：CHEMBL4402628

实验名称：Binding affinity to mushroom tyrosinase assessed as binding constant by fluorescence ...
来源：ChEMBL
靶标：Polyphenol oxidase 2
External Id：CHEMBL4402629

实验名称：Inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate after ...
来源：ChEMBL
靶标：Cytochrome P450 2C9
External Id：CHEMBL2399577

实验名称：Inhibition of CYP3A4/5 in human intestinal microsomes using midazolam as substrate af...
来源：ChEMBL
靶标：Cytochrome P450 3A4
External Id：CHEMBL2399576

实验名称：Inhibition of OATP2B1 (unknown origin) expressed in MDCK2 cells assessed as reduction...
来源：ChEMBL
靶标：Solute carrier organic anion transporter family member 2B1
External Id：CHEMBL3529886

实验名称：Inhibition of UGT in human liver microsomes using 4-methylumbelliferone as substrate ...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL2399575

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Silidianin

Silydianin

(1R,3R,6R,7R,10R)-3-Hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-4-oxatricyclo[4.3.1.0]dec-8-en-2-one

Silydianin (20 mg)

Silychristin