8-氧代黄连碱; 8-氧黄连碱

更新时间：2025-08-27 15:33:50

8-氧代黄连碱; 8-氧黄连碱结构式	常用名	8-氧代黄连碱; 8-氧黄连碱	英文名	8-Oxycoptisine
	CAS号	19716-61-1	分子量	335.310
	密度	1.6±0.0 g/cm3	沸点	617.5±0.0 °C at 760 mmHg
	分子式	C₁₉H₁₃NO₅	熔点	N/A
	MSDS	N/A	闪点	327.3±0.0 °C

8-氧代黄连碱; 8-氧黄连碱用途

8-氧可可碱是一种具有抗癌活性的天然原小檗碱生物碱[1]。

中文名	8-氧黄连碱
英文名	6,7-Dihydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-4-one
英文别名	更多

描述	8-氧可可碱是一种具有抗癌活性的天然原小檗碱生物碱[1]。
相关类别	研究领域 >> 癌症信号通路 >> 其他 >> 其他
体外研究	8-氧可可碱对NCI-N87有细胞毒性(IC50=20.31μM),对Caco-2没有细胞毒性(IC50>100μM)[1]。
参考文献	[1]. Ping Qian, et al. Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells. Fitoterapia. 2014 Mar;93:74-80.

密度	1.6±0.0 g/cm3
沸点	617.5±0.0 °C at 760 mmHg
分子式	C₁₉H₁₃NO₅
分子量	335.310
闪点	327.3±0.0 °C
精确质量	335.079010
LogP	4.65
InChIKey	UCAFJBSQKXVPDX-UHFFFAOYSA-N
SMILES	O=c1c2c3c(ccc2cc2n1CCc1cc4c(cc1-2)OCO4)OCO3
蒸汽压	0.0±0.0 mmHg at 25°C
折射率	1.768
储存条件	2-8℃

实验名称：Anti-ulcerative colitis activity in DSS-induced acute C57Bl/6J mouse ulcerative colit...
来源：ChEMBL
靶标：Mus musculus
External Id：CHEMBL3616013

实验名称：Transactivation of XBP1 in rat IEC-6 cells after 48 hrs by dual luciferase reporter g...
来源：ChEMBL
靶标：X-box-binding protein 1
External Id：CHEMBL3636117

实验名称：Transactivation of XBP1 in rat IEC-6 cells at 10 uM after 48 hrs by dual luciferase r...
来源：ChEMBL
靶标：X-box-binding protein 1
External Id：CHEMBL3636116

实验名称：Activation of XBP1 in rat IEC-6 cells assessed as transcriptional activity at 10 uM m...
来源：ChEMBL
靶标：X-box-binding protein 1
External Id：CHEMBL4477590

实验名称：Activation of XBP1 in rat IEC-6 cells assessed as transcriptional activity measured a...
来源：ChEMBL
靶标：X-box-binding protein 1
External Id：CHEMBL4477591

实验名称：Antiproliferative activity against human MGC-803 cells assessed as reduction in cell ...
来源：ChEMBL
靶标：MGC-803
External Id：CHEMBL5146743

实验名称：Transactivation of XBP1 (unknown origin) transfected in rat IEC-6 cells at 10 uM afte...
来源：ChEMBL
靶标：X-box-binding protein 1
External Id：CHEMBL3616010

实验名称：Antiproliferative activity against human HGC-27 cells assessed as reduction in cell v...
来源：ChEMBL
靶标：HGC-27
External Id：CHEMBL5146744

实验名称：Antiproliferative activity against human GES1 cells assessed as reduction in cell via...
来源：ChEMBL
靶标：GES1
External Id：CHEMBL5146745

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6,7-Dihydro-4H-[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-4-one