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D-天门冬氨酸

D-天门冬氨酸用途

(-)-Aspartic acid 是一种内源性 NMDA 受体激动剂。

D-天门冬氨酸名称

[ CAS 号 ]:
1783-96-6

[ 中文名 ]:
D-天冬氨酸

[ 英文名 ]:
H-D-Asp-OH

[中文别名 ]:

[英文别名 ]:

δ-aspartic acid
D(-)-Aspartic acid
d-Asp
QVYZ1VQ &&D or R Form
(-)-Aspartic acid
(2R)-2-Aminosuccinic acid
Aspartic acid,D
D-Aspartate
MFCD00063081
(2R)-2-aminobutanedioic acid

D-天门冬氨酸生物活性

[ 描述 ]:

(-)-Aspartic acid 是一种内源性 NMDA 受体激动剂。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> iGluR

信号通路 >> 神经信号通路 >> iGluR

研究领域 >> 神经疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

D-天门冬氨酸物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
264.1±30.0 °C at 760 mmHg

[ 熔点 ]:
300ºC

[ 分子式 ]:
C₄H₇NO₄

[ 分子量 ]:
133.103

[ 闪点 ]:
113.5±24.6 °C

[ 精确质量 ]:
133.037506

[ PSA ]:
100.62000

[ LogP ]:
-0.67

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.1 mmHg at 25°C

[ 折射率 ]:
1.531

[ 储存条件 ]:
室温

D-天门冬氨酸MSDS

D-天门冬氨酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CI9097500

CHEMICAL NAME :: D-Aspartic acid

CAS REGISTRY NUMBER :: 1783-96-6

BEILSTEIN REFERENCE NO. :: 1723529

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C4-H7-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6063 mg/kg/7D-C

TOXIC EFFECTS :: Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Metabolism (Intermediary) - other proteins

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,738,1982

D-天门冬氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
CI9097500

[ 海关编码 ]:
29224995

D-天门冬氨酸合成路线

D-天门冬氨酸上下游产品

D-天门冬氨酸上游产品

D-天门冬氨酸下游产品

D-天门冬氨酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

D-天门冬氨酸文献

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.

Nature 445 , 387-93, (2007)

Secondary transporters are integral membrane proteins that catalyse the movement of substrate molecules across the lipid bilayer by coupling substrate transport to one or more ion gradients, thereby p...

Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks.

Life Sci. 109(1) , 65-71, (2014)

L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this stud...

Okibacterium endophyticum sp. nov., a novel endophytic actinobacterium isolated from roots of Salsola affinis C. A. Mey.

Antonie van Leeuwenhoek 107(3) , 835-43, (2015)

A white bacterial strain, designated EGI 650022(T), was isolated from the roots of Salsola affinis C. A. Mey, collected from Urumqi City, Xinjiang, north-western China. The strain was found to be aero...

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