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花旗松素

花旗松素用途

Taxifolin 具有重要的抗酪氨酸酶活性。Taxifolin 有效抑制胶原酶 (collagenase),IC50 为 193.3 μM。

花旗松素作用

花旗松素能够剂量依赖性抑制卵巢癌细胞生长。与Qercetin相比，花旗松素不会致突变，且具有低毒性。花旗松素通过ARE依赖性机制调控基因起到潜在的化学预防作用。

花旗松素名称

[ CAS 号 ]:
480-18-2

[ 中文名 ]:
花旗松素

[ 英文名 ]:
Taxifolin

[中文别名 ]:

[英文别名 ]:

EINECS 207-543-4
Dihydroquercetin
(2R,3R)-3,3',4',5,7-Pentahydroxyflavanone
Distylin
(+)-Taxifolin
Taxifolin
MFCD00006845
(-)-taxifolin
Taxifoliol

花旗松素生物活性

[ 描述 ]:

Taxifolin 具有重要的抗酪氨酸酶活性。Taxifolin 有效抑制胶原酶 (collagenase),IC50 为 193.3 μM。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 代谢酶/蛋白酶 >> 酪氨酸酶

研究领域 >> 癌症

天然产物 >> 黄酮类化合物

[ 靶点 ]

IC50: 193.3 μM (Collagenase)[1] Tyrosinase[1]

[体外研究]

通过研究纯的紫杉叶素和(+)-儿茶素对胶原酶活性的研究证实了这一点。紫杉叶素具有显着的抑制活性,IC50值为193.3μM,而(+)-儿茶素无活性[1]。紫杉叶素是食品和草药中普遍存在的生物活性成分。紫杉醇(二氢槲皮素)是一种生物活性黄酮醇,常见于葡萄,柑橘类水果,洋葱,绿茶,橄榄油,葡萄酒和许多其他食物中,以及几种草药(如奶蓟,法国海洋树皮,花旗松树皮,和Smilacis Glabrae Rhizoma)[2]。

[体内研究]

紫杉叶素可能很容易代谢,其代谢产物是体内流行的形式,尽管有关体内Taxifolin代谢的信息有限[2]。

[动物实验]

大鼠[2]使用12只雄性Sprague-Dawley大鼠（体重180-220g）。将大鼠随机分为两组（每组6只大鼠），药物组和空白组。将紫杉叶素悬浮在0.5％CMC-Na溶液中，并以200mg / kg体重的剂量口服给予药物组，而空白组大鼠以相同体积口服给予0.5％CMC-Na溶液。所有大鼠每天（上午9:00）给药一次，持续3天。

[参考文献]

[1]. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11). pii: E1586.

[2]. Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS(n). Molecules. 2016 Sep 13;21(9). pii: E1209.

[相关活性小分子]

花旗松素物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
687.6±55.0 °C at 760 mmHg

[ 熔点 ]:
230-233°C (dec.)

[ 分子式 ]:
C₁₅H₁₂O₇

[ 分子量 ]:
304.252

[ 闪点 ]:
264.2±25.0 °C

[ 精确质量 ]:
304.058289

[ PSA ]:
127.45000

[ LogP ]:
1.82

[ 外观性状 ]:
淡黄色粉末

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.763

[ 储存条件 ]:
-20?C Freezer

花旗松素MSDS

详细MSDS(安全技术说明书)

花旗松素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK6920000

CHEMICAL NAME :: Flavanone, 3,3',4',5,7-pentahydroxy-

CAS REGISTRY NUMBER :: 480-18-2

BEILSTEIN REFERENCE NO. :: 0093548

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H12-O7

MOLECULAR WEIGHT :: 304.27

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 985 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 1 gm/L/48H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977

花旗松素安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LK6920000

[ 海关编码 ]:
2932999099

花旗松素合成路线

详细合成路线

花旗松素上下游产品

花旗松素上游产品

花旗松素下游产品

花旗松素制备

植物来源有松科植物松[Pseudotsuga taxifolia Britt. (Douglas fir)]，金缕梅科植物蚊母树(Distylium racemosum Sieb.et Zucc.)等。

花旗松素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

花旗松素文献

Combined experimental and in silico approaches for exploring antiperoxidative potential of structurally diverse classes of antioxidants on docetaxel-induced lipid peroxidation using 4-HNE as the model marker.

Bioorg. Chem. 56 , 1-7, (2014)

The objective of the present work was tantamount to explain the antiperoxidative potential and structural requirements of twenty-eight structurally diverse classes of antioxidants on docetaxel-induced...

In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase.

Toxicology 308 , 34-40, (2013)

The microsomal NADH-dependent electron transport system consisting of cytochrome b5 reductase and cytochrome b5 participates in a number of physiologically important processes including lipid metaboli...

Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 986-987 , 69-84, (2015)

Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical formula of traditional Chinese medicine, which has been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury. In this study...

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