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五味子乙素

五味子乙素用途

五味子乙素(Wuweizisu-B)是从五味子中分离联苯环辛二烯衍生物,已被证明对啮齿类动物的肝脏和心脏的抗氧化作用。

五味子乙素名称

[ CAS 号 ]:
61281-37-6

[ 中文名 ]:
五味子乙素

[ 英文名 ]:
Schizandrin B

[中文别名 ]:

五味子素乙

[英文别名 ]:

MFCD00210555
GEMA-SCHIZANDRIN
Schisandrin B

五味子乙素生物活性

[ 描述 ]:

五味子乙素(Wuweizisu-B)是从五味子中分离联苯环辛二烯衍生物,已被证明对啮齿类动物的肝脏和心脏的抗氧化作用。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

研究领域 >> 神经疾病

天然产物 >> 苯丙酸类

[参考文献]

[1]. Checker R, et al. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. Free Radic Biol Med. 2012 Oct 1;53(7):1421-30.

[2]. Lam PY, et al. Schisandrin B as a hormetic agent for preventing age-related neurodegenerative diseases. Oxid Med Cell Longev. 2012;2012:250825.

[3]. Zeng KW, et al. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol. 2012 Oct 5;692(1-3):29-37.

[4]. Liu Z, et al. Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. PLoS One. 2012;7(7):e40480.

[5]. Zhu S, et al. Protective effect of schisandrin B against cyclosporine A-induced nephrotoxicity in vitro and in vivo. Am J Chin Med. 2012;40(3):551-66.

[相关活性小分子]

五味子乙素物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
545.0±50.0 °C at 760 mmHg

[ 分子式 ]:
C₂₃H₂₈O₆

[ 分子量 ]:
400.465

[ 闪点 ]:
220.4±30.0 °C

[ 精确质量 ]:
400.188599

[ PSA ]:
55.38000

[ LogP ]:
6.46

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±1.4 mmHg at 25°C

[ 折射率 ]:
1.543

[ 储存条件 ]:
室温

五味子乙素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE8396500

CHEMICAL NAME :: Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-di methyl-, stereoisomer

CAS REGISTRY NUMBER :: 61281-37-6

LAST UPDATED :: 199309

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C23-H28-O6

MOLECULAR WEIGHT :: 400.51

WISWESSER LINE NOTATION :: T D5 B686 EO GO FH&&T&J CO1 L1 M1 QO1 RO1 SO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex)

REFERENCE :: CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 93,41,1980

五味子乙素安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2942000000

五味子乙素合成路线

详细合成路线

五味子乙素上下游产品

五味子乙素上游产品

五味子乙素下游产品

五味子乙素海关

[ 海关编码 ]: 2942000000