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乳清酸

乳清酸用途

乳清酸(OA)是嘧啶代谢过程中的中间体。

乳清酸名称

[ CAS 号 ]:
65-86-1

[ 中文名 ]:
乳清酸

[ 英文名 ]:
Orotic acid

[中文别名 ]:

[英文别名 ]:

Orotonsan
orotic
Oropur
2,6-dihydroxypyrimidine-4-carboxylic acid
Uracil-6-carboxylic acid
Orotic acid
[3H]-Orotic acid
vitamin B13
Oroturic
H-ORO-OH

乳清酸生物活性

[ 描述 ]:

乳清酸(OA)是嘧啶代谢过程中的中间体。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

天然产物 >> 生物碱

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Jung, E.J., K.Y. Lee, and B.H. Lee, Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells. J Toxicol Sci, 2012. 37(4): p. 813-21.

[2]. Manjeshwar, S., et al., The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo. Mol Carcinog, 1999. 24(3): p. 188-96.

[3]. Cha, J.Y., et al., Effect of betaine on the hepatic damage from orotic acid-induced fatty liver development in rats. J Enzyme Inhib Med Chem, 2011.

[4]. Jung, E.J., et al., Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. J Lipid Res, 2011. 52(9): p. 1617-25.

[相关活性小分子]

乳清酸物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
656.9±65.0 °C at 760 mmHg

[ 熔点 ]:
>300°C

[ 分子式 ]:
C₅H₄N₂O₄

[ 分子量 ]:
156.096

[ 闪点 ]:
351.1±34.3 °C

[ 精确质量 ]:
156.017105

[ PSA ]:
103.02000

[ LogP ]:
-1.40

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.705

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
Slightly soluble

乳清酸MSDS

乳清酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RM3180000

CHEMICAL NAME :: Orotic acid

CAS REGISTRY NUMBER :: 65-86-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C5-H4-N2-O4

MOLECULAR WEIGHT :: 156.11

WISWESSER LINE NOTATION :: T6MVMVJ FVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 841 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 770 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 120 umol/L

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 9,675,1988

乳清酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RM3180000

乳清酸合成路线

乳清酸上下游产品

乳清酸上游产品

乳清酸下游产品

乳清酸制备

1.可在制取乳糖后的副产物中提取。牛奶分去乳糖后，母液先经过阳离子交换树脂柱，洗脱液再经过阴离子交换树脂柱，收集洗脱液浓缩，静置析出结晶，过滤，即为乳清酸粗品。

2.合成法

乳清酸文献

Solubilization of gliadins for use as a source of nitrogen in the selection of bacteria with gliadinase activity.

Food Chem. 168 , 439-44, (2014)

For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrog...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

QSPR modeling of octanol/water partition coefficient for vitamins by optimal descriptors calculated with SMILES.

Eur. J. Med. Chem. 43 , 714-40, (2008)

Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and org...

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乳清酸