1083078-98-1
1083078-98-1结构式
- 常用中文名：JNJ26481585
- 常用英文名：JNJ26481585
- CAS号：1083078-98-1
- 分子式：C21H27ClN6O2
- 分子量：430.93100
- 发布时间：2016-01-22 20:13:38
- 更新时间：2024-02-04 19:13:30
-
Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.
| 英文名 | N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide,hydrochloride |
|---|---|
| 英文别名 |
Quisinostat HCl
UNII-WUV1QHM1CS Quisinostat hydrochloride |
| 分子式 | C21H27ClN6O2 |
|---|---|
| 分子量 | 430.93100 |
| 精确质量 | 430.18800 |
| PSA | 98.80000 |
| LogP | 3.92620 |