JNJ26481585

• 常用名: JNJ26481585
• 英文名: JNJ26481585
• CAS号: 1083078-98-1
• 分子量: 430.93100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₇ClN₆O₂
• 熔点: N/A
• 闪点: N/A

JNJ26481585用途

Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.

JNJ26481585名称

• 英文名: N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide,hydrochloride

JNJ26481585物理化学性质

• 分子式: C₂₁H₂₇ClN₆O₂
• 分子量: 430.93100
• 精确质量: 430.18800
• PSA: 98.80000
• LogP: 3.92620

JNJ26481585英文别名

• Quisinostat HCl
• UNII-WUV1QHM1CS
• Quisinostat hydrochloride