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| 中文名 | 硫酸奎尼丁二水合物 |
|---|---|
| 英文名 | Quinidine sulfate salt dihydrate |
| 中文别名 |
奎尼定硫酸盐
硫酸奎尼丁 硫酸奎尼丁 |
| 英文别名 |
Quinidine Sulfate Dihydrate
Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate, hydrate (2:1:2) (salt) EINECS 200-046-3 (9S)-6'-Methoxycinchonan-9-ol sulfate hydrate (2:1:2) MFCD00149346 |
| 描述 | Quinidine sulfate dihydrate 是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,可在体内抑制苯丙胺的代谢。Quinidine sulfate dihydrate 增强长春新碱 (VCR) 在肿瘤细胞中的细胞毒性,尤其是在 P388 白血病 (P388/VCR) 和人骨髓性白血病的VCR 耐药亚型中。 |
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| 相关类别 | |
| 靶点 |
IC50: cytochrome P450db; amphetamine metabolism[1] |
| 参考文献 |
| 沸点 | 992.5ºC at 760 mmHg |
|---|---|
| 熔点 | 212-214 °C (dec.)(lit.) |
| 分子式 | C20H24N2O2.1/2H2O4S.H2O |
| 分子量 | 782.943 |
| 闪点 | 554ºC |
| 精确质量 | 782.356079 |
| PSA | 192.62000 |
| LogP | 6.52160 |
| 外观性状 | 固体 |
| 折射率 | 275 ° (C=2, 0.1mol/L HCl) |
| 储存条件 | 室温 |
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Section 1. Chemical Product and Company Identification Quinidine sulfate dihydrateCatalog QU105 Common Name/ Number(s). Trade Name CAS#6591-63-5
Manufacturer RTECSVA5950000 SPECTRUM CHEMICAL MFG. CORP. TSCATSCA 8(b) inventory: Quinidine sulfate dihydrate Commercial Name(s)Not available. CI# Not available. Synonym6'-Methoxycinchonan-9-ol sulfate IN CASE OF EMERGENCY Not available. Chemical Name Chemical FamilyNot available.CALL (310) 516-8000 (C20H24N2O2)2.H2SO4.2H2O Chemical Formula SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) NameCAS #% by Weight 1) Quinidine sulfate dihydrate6591-63-5100 Toxicological DataQuinidine sulfate dihydrate on IngredientsLD50: Not available. LC50: Not available. Section 3. Hazards Identification Potential Acute Health Effects Very hazardous in case of ingestion. Hazardous in case of eye contact (irritant), of inhalation. Potential Chronic HealthVery hazardous in case of ingestion. EffectsHazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. Quinidine sulfate dihydrate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention. Skin ContactNo known effect on skin contact, rinse with water for a few minutes. Serious Skin ContactNot available. InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention. Serious InhalationNot available. IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...). Fire Hazards in Presence of Not available. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Large SpillUse a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Quinidine sulfate dihydrate Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Avoid contact with eyes Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible. StorageKeep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Personal Protection in Case of Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a a Large Spillspecialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystals solid.)OdorOdorless. TasteBitter. Molecular Weight782.96 g/mole ColorWhite. pH (1% soln/water)Not available. Not available. Boiling Point Melting PointDecomposes. (120°C or 248°F) Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water, methanol. SolubilitySoluble in methanol. Partially soluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityNot available. Incompatibility with various Not available. substances Quinidine sulfate dihydrate CorrosivityNon-corrosive in presence of glass. Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationNo. Section 11. Toxicological Information Routes of EntryEye contact. Inhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion. HumansHazardous in case of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onHuman: passes through the placenta, excreted in maternal milk. Chronic Effects on Humans Special Remarks on otherNot available. Toxic Effects on Humans Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsThe products of degradation are more toxic. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste Disposal Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). IdentificationNot applicable. Special Provisions forNot applicable. Transport Quinidine sulfate dihydrate DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Quinidine sulfate dihydrate Federal and State Regulations California Proposition 65 Warnings Other RegulationsNot available.. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R36- Irritating to eyes. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection j WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Not applicable. Lab coat. Not applicable. Splash goggles. SECTION 16 - ADDITIONAL INFORMATION N/A |
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CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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